POM-V Prescription Required

Combiclav Suspension for Injection

Active ingredients: Amoxicillin, Clavulanic Acid

Form

Injection

Species

Cattle

Manufacturer

Norbrook Laboratories Limited

VMD MA No.

02000/4238

What it's used for

Combiclav Injection has a broad spectrum of bactericidal activity against the bacteria commonly found in cattle. (a) Combiclav Injection is active against...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Prescription required

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Clinical information

Combiclav Suspension for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Combiclav Injection has a broad spectrum of bactericidal activity against the bacteria
commonly found in cattle.
(a) Combiclav Injection is active against a wide range of clinically important
bacteria including:
Gram-positive: Staphylococci (including beta-lactamase producing strains), Streptococci,
Corynebacteria, Clostridia, Bacillus anthracis, Actinomyces bovis.
Gram-negative: (including beta-lactamase producing strains),
Salmonella spp (including beta-lactamase producing strains), spp,
Klebsiella spp, spp, spp, , Bacteroides
(including beta-lactamase producing strains), spp,
Actinobacillus lignieresi.

Revised: July 2018
AN: 02259/2017
(b) Treats:
Cattle:
Respiratory infections
Soft tissue infections (e.g. joint/navel ill, abscesses etc.)
Metritis
Mastitis.
Combined Therapy for the treatment of bovine mastitis. In the situation where systemic
treatment as well as intramammary treatment is necessary, Combiclav Injection can be
administered in combination with Combiclav Lactating Cow Intramammary Suspension.

Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
The product should not be administered to rabbits, guinea pigs, hamsters or gerbils.
Caution is advised in its use in other very small herbivores.

Use of the product may occasionally result in pain on injection and/or local tissue
reaction.

None.

i) Special precautions for use in animals
Official and local antimicrobial policies should be taken into account when the product is
used.
Use of the product should be based on susceptibility testing of the bacteria isolated from
the animal. If this is not possible, therapy should be based on local epidemiological
information.
Avoid use of the product in herds where no producing strains
have been isolated. Veterinarians should strive to use narrow spectrum antibiotics if
possible.
Inappropriate use of the product may increase the prevalence of bacteria resistant to ß-
lactam antibiotics and may decrease the effectiveness of treatment with ß-lactam
antibiotics, due to the potential for cross-resistance.
Care should be taken to avoid contaminating the remaining contents of a vial with water.
Clavulanic acid is moisture sensitive. It is very important therefore, that a completely dry
needle and syringe is used when extracting suspension for injection in order to avoid
contaminating the remaining contents of the vial with drops of water.

Revised: July 2018
AN: 02259/2017
Contamination will result in obvious beads of dark, brown discolouration corresponding to
the introduced water droplets. Material affected in this way should not be used as it may
have significantly reduced potency.
ii) Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-
reactions to cephalosporins and vice versa. Allergic reactions to these substances may
occasionally be serious.
Care should be taken to avoid accidental self-injection.
Do not handle this product if you know you are sensitised, or if you have been advised not
to work with such preparations.
Handle this product with great care to avoid exposure, taking all recommended
precautions.
If you develop symptoms following exposure such as a skin rash, you should seek
medical advice and show the doctor this warning. Swelling of the face, lips or eyes or
difficulty in breathing are more serious symptoms and require urgent medical attention.
Wash hands after use.

None known.

Do not store above 25ºC.
Keep container in outer carton
Discard unused material.
This product does not contain an antimicrobial preservative.
Once a vial has been broached the contents should be used within 28 days.

Meat and offal: 42 days.
Milk: 60 hours
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.