Coliscour Oral Solution of Colistin Sulphate 2 MIU/ml

Oral use.
Administration via drinking water or direct application by mouth, after dilution with
drinking water.
Dosage: 50 000 IU/kg of colistin per kg body weight twice a day for 5 days, i.e. 0.25
ml of Coliscour Solution per 10 kg of body weight twice a day for 5 consecutive days.
Individual administration
For suckling piglets the product should be administered only on an individual basis.
Coliscour solution should be diluted in drinking water. Take 1 ml of Coliscour solution
and dilute to 40 ml with drinking water.
Administration of this diluted solution is by direct application in the mouth with a
syringe: 1 ml per kg bodyweight twice a day for 5 consecutive days.
The used syringe must allow a precision of 0.2 ml.

Revised: October 2025
AN: 01814/2025
Administration via drinking water
The medicated water should be the only source of drinking water for the animals for
the entire duration of the treatment period (2 to 6 hours).
In order to ensure that the product is effectively consumed in less than 6 hours, it
might be advised to:
Restrict water for one hour just before the treatment period, if the clinical condition of
the animals allows this.
Or to slightly underestimate the consumption of water which will lead to a shortened
treatment period.
Administration without a dosing pump:
The treatment is distributed in a tank in a pulse mode over a period of 2 to 6 hours,
twice a day, for 5 consecutive days.
Coliscour solution is added to a volume of the drinking water corresponding to the
volume consumed by the animals over the treatment period (2 to 6 hours) to achieve
a dose rate of 50 000 IU of colistin per kg body weight.
The following sequential steps should be followed:
From the dosage regimen and the total weight of pigs to be treated, determine the
necessary quantity of active ingredient, and deduce the necessary quantity of
commercial product.
Determine the mean water consumption of the animals to be treated over the
treatment period (2 to 6 hours), and deduce the total quantity of supplemented water
to prepare.
The following formulae can be applied:
Calculation of Coliscour solution volume at each distribution (V):
V (ml) = (50 000*W)/(2 000 000) where W (kg) = total weight of pigs to treat
Or 0.025ml x W (kg) of bodyweight.
Calculation of the quantity of supplemented drinking water to prepare (Q) :
Q (L) =A x N where A = mean individual water consumption of the animals during
the scheduled distribution period in litres
where N = number of animals to be treated
Administration via a dosing pump
The treatment is distributed in a pulse mode over a period of 2 to 6 hours, twice a
day, for 5 consecutive days.
A dosing pump is used to add a stock solution at a pre-determined concentration to
the drinking water. The pumped volume is constant, but the drinking frequency
depends on the flow rate of the circuit. The flow rate (F) through the pump is a
percentage.
Thus, the concentration of the stock solution corresponds to the concentration of the
solution to be distributed to the animals divided by the flow rate through the pump.
If the product is administered with an automated drinking water system, the following
sequential steps should be followed:

Revised: October 2025
AN: 01814/2025
Determine the quantity of Coliscour solution to achieve a dose rate of 50 000 IU
colistin per kg body weight.
Determine the mean water consumption of the animals to be treated over the
scheduled treatment period (2 to 6 hours).
Calculate the concentration of the solution to be distributed to the animals
Calculate from this, the concentration of the stock solution, knowing the flow rate of
the dosing pump.
1ml of Coliscour solution contains 2 000 000 IU.
The following calculation must be applied:
Calculation of Coliscour solution volume at each distribution (V) :
V (ml) = (50 000 x W)/(2 000 000) where W (kg) = total weight of pigs to treat
Or 0.025ml x W( kg) of bodyweight.
Calculation of the drinking water concentration (C) :
C (ml/L) = V/B where B = total volume of water consumed by the pigs during
the scheduled distribution period (2 to 6 hours)
Calculation of the stock solution volume (V’) :
V’ (L) = B*F where F= flow rate through the dosing pump as a percentage
Calculation of the stock solution concentration (C’) :
C’ (ml/L) = C/F
The veterinary surgeon should provide suitable advice to the farmer including
prevention, by vaccination of sows, and hygiene methods that might aid in prevention
of the disease such as adoption of all-in-all-out procedures in farrowing units.
Duration of treatment should be limited to the minimum time necessary for the
treatment of the disease.