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POM-V Prescription Required

Circovac Emulsion and Suspension for Emulsion for Injection for Pigs

Active ingredient: Porcine circovirus-2

Form

Injection

Species

Pigs

Manufacturer

Ceva Animal Health Ltd

VMD MA No.

15052/5027

What it's used for

Onset of immunity: 2 weeks Duration of immunity: at least 23 weeks after vaccination Sows and gilts: Passive immunisation of piglets via the colostrum, aft...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Prescription required

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Clinical information

Circovac Emulsion and Suspension for Emulsion for Injection for Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity: 2 weeks
Duration of immunity: at least 23 weeks after vaccination
Sows and gilts: Passive immunisation of piglets via the colostrum, after active
immunisation of sows and gilts, to reduce lesions in lymphoid tissues associated with
PCV2 infection and as an aid to reduce PCV2-linked mortality.
Duration of immunity: up to 5 weeks after transfer of passive antibodies through colostrum
intake.
To use the vaccine, shake vigorously the vial of antigen suspension and inject its content
into the vial of emulsion containing adjuvant. Gently mix before use. The reconstituted
vaccine is a homogeneous white emulsion.
When Circovac is used alone
Piglets from 3 weeks of age:
Administer one 0.5 ml dose by deep intramuscular injection.
Gilts and sows:
Administer one 2 ml dose by deep intramuscular injection in accordance with the following
vaccination scheme:
Basic vaccination:
● Gilts: One injection, followed 3 to 4 weeks later by a second injection, at least 2 weeks
before mating. One further injection must be given, at least 2 weeks before farrowing.
● Sows: One injection, followed 3 to 4 weeks later by a second injection, at least 2 weeks
before farrowing.
Revaccination:
● One injection at each gestation, at least 2 to 4 weeks before farrowing.
When Circovac is mixed with Hyogen:
The mixed use is restricted to the 100 doses (200 ml) presentations of Hyogen and to the
100 doses presentations (50 ml of reconstituted vaccine) of Circovac.
Piglets from 3 weeks of age:
CircovacHyogen100 doses for piglets (50 ml
of reconstituted suspension
+ emulsion)
100 doses (200 ml of vaccine) in
250 ml bottle
Vaccine devices should be used under aseptic conditions and in accordance with the
device instructions provided by the manufacturer.
Prepare Circovac by shaking vigorously the vial of antigen suspension and injecting its
content into the vial of emulsion containing adjuvant.
Mix 50 ml of Circovac and 200 ml of Hyogen and shake gently until a homogeneous white
emulsion is obtained.
Administer one 2.5 ml dose of the mixture by intramuscular injection, in the side of the
neck.
Use the entire vaccine mixture immediately after mixing.
None.
Pigs (gilts, sows and piglets from 3 weeks of age):
Very common
(>1 animal / 10 animals treated):
Injection site swelling
, Injection site reddening
,
Injection site oedema
Injection site skin discolouration
, Injection site
granuloma
, Injection site fibrosis
, Injection site
necrosis
Rare
(1 to 10 animals / 10,000
animals treated):
Hyperthermia
,
Apathy
, Decreased appetite
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reaction
Abortion
Swelling (up to 2 cm
in average) and redness (up to 3 cm
in average), and in some
cases oedema (up to 17 cm
in average). These reactions resolve spontaneously in
maximum 4 days in average without any consequence on the health and the
zootechnical performances.
In sows at most 50 days after the vaccination limited lesions such as a discoloration
and a granuloma, as well as necrosis or fibrosis may occur. In piglets, due to the smaller
dose volume used, less extended lesions and limited fibrosis may be observed at time of
slaughter.
Within the 2 days following the injection, an average increase in rectal temperature of
up to 1.4 °C can occur. An increase in rectal temperature of higher than 2.5 °C, lasting
less than 24 hours, may occur.
Should resolve spontaneously.
In such cases, an appropriate symptomatic treatment should be provided.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Vaccinate healthy animals only.
Piglets: The efficacy of the vaccine in the face of intermediate to high levels of maternally
derived antibodies has been demonstrated.

Special precautions for safe use in the target species:
Apply usual procedures for the handling of animals. Apply usual aseptic procedures.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
To the user:
This veterinary medicinal product contains mineral oil. Accidental injection/self-injection
may result in severe pain and swelling, particularly if injected into a joint or finger, and in
rare cases could result in the loss of the affected finger if prompt medical attention is not
given.
If you are accidentally injected with this veterinary medicinal product, seek prompt medical
advice even if only a very small amount is injected and take the package leaflet with you.
If pain persists for more than 12 hours after medical examination, seek medical advice
again.
To the physician:
This veterinary medicinal product contains mineral oil. Even if small amounts have been
injected, accidental injection with this veterinary medicinal product can cause intense
swelling, which may, for example, result in ischaemic necrosis and even the loss of a digit.
Expert, PROMPT, surgical attention is required and may necessitate early incision and
irrigation of the injected area, especially where there is involvement of finger pulp or
tendon.
Special precautions for the protection of the environment:
Not applicable
Safety and efficacy data are available which demonstrate that this vaccine can be mixed
with Hyogen and administered to piglets at one injection site. When mixed with Hyogen,
vaccinate only piglets from 3 weeks of age.
Onset of immunity: 3 weeks after vaccination when mixed with Hyogen
Duration of immunity: at least 23 weeks when mixed with Hyogen.
In case of mixing with Hyogen, slight and transient local reactions may occur very
commonly after the administration, mainly swelling (0.5 cm - 5 cm), mild pain and redness
as well as in some cases oedema.
These reactions resolve spontaneously within maximum 4 days. Transient lethargy may
occur very commonly on the day of vaccination which resolves spontaneously within 1-2
days. An increase in individual rectal temperature of up to 2.5°C may occur commonly
lasting less than 24 hours. The above adverse reactions were observed in clinical studies.
When Circovac is used mixed with Hyogen the data available are not sufficient to exclude
the interaction of maternally derived antibodies against Mycoplasma hyopneumoniae with
vaccine uptake. Interaction with maternally derived antibodies is known and should be
taken into consideration. It is recommended to delay vaccination in piglets with residual
MDA against at the age of 3 weeks.
The product literature of Hyogen should be consulted before mixed administration.
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product, except when mixed with Hyogen. A decision to use
this vaccine before or after any other veterinary medicinal product therefore needs to be
made on a case by case basis.
Store and transport refrigerated (2 °C - 8 °C). Do not freeze. Store in the original package
in order to protect from light.
Zero days

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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