Cephacare Flavour 250 mg Tablets for Dogs
Active ingredient: Cefalexin
Form
Tablet
Species
Manufacturer
Ecuphar NV
VMD MA No.
32742/4028
What it's used for
Pharmacodynamics Cefalexin is an antibacterial belonging to the group of antibiotics, and is structurally analogous to and has similar mode of action to pe...
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Prescription required
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Cephacare Flavour 250 mg Tablets for Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Cefalexin is an antibacterial belonging to the group of antibiotics,
and is structurally analogous to and has similar mode of action to penicillins.
It belongs to the first generation of cephalosporins.
The β-lactam
inhibition of transpeptide and carboxypeptide enzymes, causing an osmotic
imbalance that destroys growing bacteria. Cefalexin is active against gram-
positive bacteria such as Staphylococcus aureus (including betalactamase-
producing strains), other staphylococci which do or do not produce penicillinases,
and
spp., including
Critical concentrations (cutting points or breakpoints) sensitivity (S) and
resistance (R), in µg/ml, for first generation cephalosporins (CLSI, 2013):
Susceptible: ≤≥ 32. The main mechanisms of
resistance against beta-lactams are the production of enzymes (beta-
lactamases) that inactivate the drug, the alteration of penicillin-fixing proteins and
the alteration of the permeability of the bacterial outer membrane. Cephalosporins
are generally not sensitive to the action of beta-lactamases.
There is a cross-resistance (involving the same resistance mechanism) between
antibiotics of the beta- lactam group due to structural similarities. It occurs with
beta-lactamase enzymes, structural changes in porins, or changes in efflux
pumps. Co-resistance (involving different resistance mechanisms) has been
described in E.coli due to the fact that a plasmid carries various genes encoding
resistance.
The veterinary medicinal product has a break mark on one side. To enable more
accurate dosing, half tablets may be used as necessary.
Treatment for five days is recommended. Any increase in dose or duration of use
should be according to the benefit-risk assessment by the responsible veterinarian
(e.g. in cases of chronic pyoderma).
Tablets may be added to food if necessary.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
AN: 02159/2024 & 02163/2024
The use of cefalexin tablets of lower strengths is advised for dogs with lower body
weights.
cephalosporins, to other substances of the
Do not use in rabbits, gerbils, guinea pigs and hamsters.
Rare (1 to 10 animals / 10,000
animals treated):
Hypersensitivity
*
Undetermined frequency
(cannot be estimated from the
available data):
Diarrhoea
**
, vomiting
**
*
When observed, the treatment should be discontinued and occurring symptoms should be treated
symptomatically.
**
When observed, treatment should be stopped and the advice of the attending veterinarian should be
sought.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
AN: 02159/2024 & 02163/2024
Special precautions for safe use in target species:
Use of the veterinary medicinal product should be based on susceptibility testing and
take into account official and local antimicrobial policies.
Use of the veterinary medicinal product deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to cefalexin and may
decrease the effectiveness of treatment with penicillins, due to the potential for cross-
resistance.
In the case of an allergic reaction, treatment should be withdrawn.
As with other antibiotics which are excreted mainly by the kidneys, unnecessary
accumulation may occur in the body when renal function is impaired. In cases of
known renal insufficiency the dose should be reduced, antimicrobials known to be
nephrotoxic should not be administered concurrently and the veterinary medicinal
product should be used only according to the benefit-risk assessment by the
responsible veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillin may lead
to cross-reactions to cephalosporin and vice versa. Allergic reactions to these
substances may occasionally be serious.
People with known hypersensitivity to cefalexin should avoid contact with the
veterinary medicinal product.
Handle this veterinary medicinal product with great care to avoid exposure, taking all
recommended precautions. If you develop symptoms following exposure such as skin
rash, you should seek medical advice and show the doctor this warning. Swelling of
the face, lips or eyes or difficulty breathing are more serious symptoms and require
urgent medical attention.
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
AN: 02159/2024 & 02163/2024
of bacteriostatic acting compounds (macrolides, sulphonamides and tetracyclines).
Nephrotoxicity can be increased when 1st generation cephalosporins are combined
with polypeptide antibiotics, aminoglycosides and some diuretics (furosemide).
Concomitant use with such active substances should be avoided.
Store in a dry place.
Keep the blister in the outer carton.
4.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Cefalexin
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Cefabactin 1000 mg Tablets for Dogs
POM-VLe Vet Beheer B.V.
Cefabactin 1000 mg Tablets for Dogs
POM-VLe Vet Beheer B.V.
Cefabactin 250 mg Tablets for Dogs and Cats
POM-VLe Vet Beheer B.V.
Cefabactin 250 mg Tablets for Dogs and Cats
POM-VLe Vet Beheer B.V.
Cefabactin 50 mg Tablets for Dogs and Cats
POM-VLe Vet Beheer B.V.
Cefabactin 50 mg Tablets for Dogs and Cats
POM-VLe Vet Beheer B.V.
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