POM-VPS Prescription Required

Bovilis Leptavoid–H Suspension for Injection for Cattle

Active ingredient: Leptospira hardjo

Form

Injection

Species

Cattle

Manufacturer

Intervet International B.V.

VMD MA No.

06376/4112

What it's used for

For the active immunisation of cattle from 1 month of age against Leptospira interrogans serovar Hardjo and Leptospira borgpetersenii serovar Hardjo. To re...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Leptospira hardjo

1

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Clinical information

Bovilis Leptavoid–H Suspension for Injection for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the active immunisation of cattle from 1 month of age against Leptospira
interrogans serovar Hardjo and Leptospira borgpetersenii serovar Hardjo.
To reduce shedding of Leptospira interrogans serovar Hardjo in urine.
To improve herd fertility when infertility is diagnosed as caused by Leptospira
Hardjo.
Circulating antibody is detectable 14 days following the first injection and
persists for 12 months following completion of the primary course. Conjunctival
challenge demonstrates 12 months cross protection against Leptospira
borgpetersenii serovar Hardjo subtype Hardjobovis.
In addition to the circulating antibody response, vaccination with Bovilis
Leptavoid-H also stimulates cell-mediated immunity to Leptospira

Revised: November 2024
AN: 01815/2024
borgpetersenii serovar Hardjo which is maintained for at least five months and
responds in the event of a challenge five months post vaccination.

Minimum age of administration: 1 month.
Dose: 2 ml.
Route of administration: Subcutaneous injection.
The container should be well shaken to re-suspend the precipitate before doses
are withdrawn. The vaccine should be deposited beneath the skin covering the
chest wall, well behind the shoulder, or beneath the skin covering the side of the
neck.

Revised: November 2024
AN: 01815/2024
Syringes and needles should be sterilised before use and the injection made
subcutaneously through an area of clean, dry skin taking precautions against
contamination. Exercise care with part used containers and discard all part used
containers within 8 hours of opening to reduce the potential for contamination.
Use a draw-off needle in the vial stopper to avoid excess broaching of the
stopper.
Vaccination regime
Primary course
The primary course consists of two doses with an interval of at least 4 weeks
and not more than 6 weeks between them. Ideally the course should be
completed in the spring before the main season of transmission of Leptospira
Hardjo.
Re-vaccination
Re-vaccination with a single dose should be given annually to maintain
protection against infection and progressively reduce exposure in the herd.
If the primary course is given later than the spring, the first booster should be
given in the following spring and annually thereafter.
Youngstock vaccination
If the calves are inoculated before 5 months of age, a further primary course
should be given at that age (allowing an interval of 4 weeks between
vaccinations), as otherwise maternally derived antibodies may interfere with the
immune response.
Older calves not immediately exposed to infection can be given the initial
course at any time, but it is advisable to complete vaccination shortly before the
main season of transmission of leptospirosis.
To improve herd fertility
For maximum benefit the primary course should be completed within 12 months
of infertility being diagnosed as caused by Leptospira Hardjo.

None.

A transient rise in temperature of 1 – 1.3 °C lasting 24 – 48 hours after
vaccination may occur, particularly after the second dose. This reaction is very
common.
Administration of the first and second dose may produce swellings in most
animals with diameters of up to 7.5 and 8.5cm respectively. These local
reactions normally resolve over several weeks after administration, but may
persist for longer in a small number of animals. Local reactions are very
common.
Occasional hypersensitivity reactions may occur. In the case of hypersensitivity
the use of adrenaline or other appropriate treatment is recommended.

Revised: November 2024
AN: 01815/2024
Youngstock vaccination
The sizes of the reactions seen in the second primary course may be larger
than those seen in the first primary course (up to 17 cm after 5 vaccinations 28
days apart).
There may also be an increased sensitivity at the injection site compared to the
primary vaccination. Animals may also exhibit a transient rise in temperature of
1.2 – 2.6 °C following the second primary course. See section 4.9 for dosing
recommendations.
The frequency of adverse reactions is defined using the following convention:

the course of one treatment)





Vaccinated cattle may be positive for diagnostic tests and therefore
unacceptable for export to some countries.

Special precautions for use in animals
The vaccine should not be administered within two weeks of breeding as this
may reduce conception rates. This may be due to handling stress rather than a
specific vaccine effect. Such effects are transient, are unlikely to be above 10%
and are minor when compared with the potential overall increase in conception
rates demonstrated in Leptospira Hardjo infected herds. However, it should be
considered when timing A.I. especially with valuable semen.
Maternally derived antibody may interfere with the performance of the vaccine
in young animals. Refer to section 4.9 for appropriate dosing recommendations.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
In the case of accidental self-injection, wash the area immediately with water. If
symptoms develop, seek medical advice immediately and show the package
leaflet or the label to the physician.
Even though animals may have been vaccinated it should be remembered that
no vaccine is 100 % effective and that the risk, albeit very much reduced, of
transmission of leptospirosis from cattle to their handlers, remains. Appropriate
precautions should be maintained at all times and prompt medical advice
sought in the event of clinical signs of possible infection.

interaction
Safety and efficacy data are available which demonstrate that this vaccine can
be administered to animals of 8 month of age or older on the same day, with
Bovilis BVD vaccine. The two vaccines should be administered at separate
sites. For the concurrent use of Bovilis Leptavoid-H and Bovilis BVD vaccines in
naïve animals, the primary vaccination course must be completed at least 4
weeks before the expected gestation, in order that foetal protection can be
established.
No information is available on the safety and efficacy of this vaccine when used
with any other veterinary medicinal product except the product mentioned
above. A decision to use this vaccine before or after any other veterinary
medicinal product therefore needs to be made on a case by case basis.

Store and transport refrigerated (2 °C – 8 °C).
Protect from light. Do not freeze.

Zero days.

Revised: November 2024
AN: 01815/2024
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.