POM-V Prescription Required

Bimotrim Co Injection Solution for Injection

Active ingredients: Sulfadoxine, Trimethoprim

Form

Injection

Species

Cattle Horses

Manufacturer

Bimeda Animal Health Limited

VMD MA No.

50146/4027

What it's used for

The in vitro activity covers most common Gram-positive and Gram-negative bacteria including Actinobacillus spp., bovis, Bordetella spp., Corynebacterium sp...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Sulfadoxine + Trimethoprim

1

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2

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Prescription required

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Clinical information

Bimotrim Co Injection Solution for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

The in vitro activity covers most common Gram-positive and Gram-negative
bacteria including Actinobacillus spp., bovis, Bordetella spp.,
Corynebacterium spp., Klebsiella spp., Listeria, Nocardia spp.,
Pasteurella spp., Proteus spp., Salmonella spp., spp., and
Streptococcus spp.
Indications: The injection may be used in the treatment of a wide range of
diseases and conditions of bacterial origin in cattle and horses.
Respiratory infections of bacterial origin including pneumonia, rhinitis, bronchitis
and secondary bacterial infections following virus pneumonia mycoplasmal
infections.

Revised: October 2018
AN: 00828/2018
Urogenital tract infections including cystitis, vaginitis, urethritis, nephritis and
metritis.
Alimentary tract infections, neonatal diarrhoea, salmonellosis and post- weaning
enteritis.

Dose: 15mg/kg (equivalent to 1 ml per 16 kg bodyweight) daily. Daily dosing
should be repeated for two days after symptoms have resolved up to a
maximum of 5 days.
Route of administration:
Cattle:By slow intravenous or intramuscular injection. Intramuscular injection is
the preferred route and should be given into the neck.
Horses: By slow intravenous injection.

Do not administer by the intraperitoneal or subcutaneous route.
Do not administer to horses exhibiting cardiac arrhythmias. Such arrhythmias
may be associated with the administration of certain anaesthetic and sedative
agents.

Very occasionally, temporary irritating swellings may appear at the site of
injection.

Very occasionally, temporary irritating swellings may appear at the site of
injection.

i. Special precautions for use in animals
The following warnings are applicable to all Trimethoprim Sulfonamide
combinations for use in the horse.
1. Cardiac and respiratory shocks in horses have been observed,
mostly after intravenous injection.
2. The injection solution should be approximately at body temperature.
At the first signs of intolerance, the injection should be interrupted
and shock treatment initiated. The product should be injected
slowly over as long a period as is reasonably practical.
3. The intravenous route of administration is contra-indicated in the
case of previous or concurrent administration of central nervous
system depressants (e.g. anaesthetics, neuroleptics).
4. The possibility of an anaphylactic or hypersensitivity reaction
occurring following administration on rare occasions must be borne
in mind.
5. As with all trimethoprim sulphonamide formulations the possibility of
potential damage to the kidney or liver or haematopoetic system
should be considered.
ii. Special precautions to be taken by the person administering the
veterinary medicinal product to animals
Care should be taken to avoid accidental injection and contact with the
skin.
Wash hands after use.
Sulphonamides may cause hypersensitivity (allergy) following, injection,
inhalation, ingestion or skin contact. Hypersensitivity to sulphonamides
may lead to cross reactions with other antibiotics. Allergic reactions to
these substances may occasionally be serious.

Revised: October 2018
AN: 00828/2018
Do not handle this product if you know you are sensitive to
sulphonamides.
If you develop symptoms following exposure such as skin rash, you
should seek medical advice and show the doctor this warning.

Because of the competitive action of the sulphonamides, their activity may be
antagonised by the presence of any of the following:
1. Para-Aminobenzoic acid (PABA) and related compounds, particularly
local anaesthetics with a PABA nucleus such as procaine, butacaine and
benzocaine, but also compounds associated with those such as procaine
penicillin. It is recommended that local anaesthetics of the procaine group
should not be used during treatment with Bimotrim Co Injection.
2. Some members of the Vitamin B complex, such as nicotinamide, folic
acid, choline and precursors of these.
3. Proteins which combine loosely with the sulphonamides and at least
temporarily reduce their antibacterial activity. Gelatin, albumin, peptone
and serum protein all antagonise the sulphonamides. Associated with this
group are products of cell and tissue death, especially pus, which also
acts as a non-vascular, mechanical barrier.
4. A number of other compounds, including enzymes, glucose and mercuric
chloride, are all reported to have antagonistic effects against
sulphonamides.

Do not freeze.
Do not store above 25°C.
Protect from light.
Following withdrawal of the first dose use the product within 28 days.
Discard unused material.

potential damage to the kidney or liver or haematopoetic system
should be considered.
ii. Special precautions to be taken by the person administering the
veterinary medicinal product to animals
Care should be taken to avoid accidental injection and contact with the
skin.
Wash hands after use.
Sulphonamides may cause hypersensitivity (allergy) following, injection,
inhalation, ingestion or skin contact. Hypersensitivity to sulphonamides
may lead to cross reactions with other antibiotics. Allergic reactions to
these substances may occasionally be serious.

Revised: October 2018
AN: 00828/2018
Do not handle this product if you know you are sensitive to
sulphonamides.
If you develop symptoms following exposure such as skin rash, you
should seek medical advice and show the doctor this warning.
4.6 Adverse reactions (frequency and seriousness)
Very occasionally, temporary irritating swellings may appear at the site of
injection.
4.7 Use during pregnancy, lactation or lay
Studies during pregnancy have not been conducted. Use with care in pregnant
animals.
4.8 Interaction with other medicinal products and other forms of interactions
Because of the competitive action of the sulphonamides, their activity may be
antagonised by the presence of any of the following:
1. Para-Aminobenzoic acid (PABA) and related compounds, particularly
local anaesthetics with a PABA nucleus such as procaine, butacaine and
benzocaine, but also compounds associated with those such as procaine
penicillin. It is recommended that local anaesthetics of the procaine group
should not be used during treatment with Bimotrim Co Injection.
2. Some members of the Vitamin B complex, such as nicotinamide, folic
acid, choline and precursors of these.
3. Proteins which combine loosely with the sulphonamides and at least
temporarily reduce their antibacterial activity. Gelatin, albumin, peptone
and serum protein all antagonise the sulphonamides. Associated with this
group are products of cell and tissue death, especially pus, which also
acts as a non-vascular, mechanical barrier.
4. A number of other compounds, including enzymes, glucose and mercuric
chloride, are all reported to have antagonistic effects against
sulphonamides.
4.9 Amounts to be administered and administration route
Dose: 15mg/kg (equivalent to 1 ml per 16 kg bodyweight) daily. Daily dosing
should be repeated for two days after symptoms have resolved up to a
maximum of 5 days.
Route of administration:
Cattle:By slow intravenous or intramuscular injection. Intramuscular injection is
the preferred route and should be given into the neck.
Horses: By slow intravenous injection.
4.10 Overdose (symptoms, emergency procedure. antidotes), if necessary
Do not exceed the recommended dose or treat animals for more than 5
consecutive days.

Revised: October 2018
AN: 00828/2018
4.11 Withdrawal periods
Cattle: Meat & offal: 10 days. Milk: 60 hours
Horses: Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption
under national horse passport legislation.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.