POM-V Prescription Required

Bimacure 500mg Intrauterine Suspension for Cattle

Active ingredient: Cefapirin

Form

Suspension

Species

Cattle

Manufacturer

Bimeda Animal Health Limited

VMD MA No.

50146/4045

What it's used for

For the treatment of subacute and chronic endometritis in cows (at least 14 days after parturition) caused by bacteria susceptible to cefapirin.

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Cefapirin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Bimacure 500mg Intrauterine Suspension for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of subacute and chronic endometritis in cows (at least 14 days
after parturition) caused by bacteria susceptible to cefapirin.

The contents of one syringe should be introduced into the lumen of the uterus using
the disposable catheter provided as follows:
1. The product may settle but can be re-suspended by gentle shaking into a
homogeneous suspension.
2. Fix the syringe to the catheter.
3. Take the cervix of the uterus into one gloved hand introduced into the
rectum.
4. Introduce the catheter through the cervix into the lumen of the uterus, by
gentle oscillating movements of the cervix.
5. Inject the contents of the syringe into the uterus.
Depending on the response, a second treatment 7-14 days later may be required in
some cases if clinical signs persist.
In animals that have been inseminated the product may be used one day after
insemination. In cases of pyometra, pre-treatment with prostaglandin is
recommended in order to induce luteolysis and remove debris from the uterine cavity.

Do not use in in animals with known hypersensitivity to cephalosporins or to any of
the excipients.

Allergic reactions have been observed in very rare cases.
The frequency of adverse reactions is defined using the following convention:
•
reaction(s))
•
•
•
•
reports).

None.

Special precautions for use in animals
Use of the product should be based on susceptibility testing of the bacteria isolated
from the animal. If this is not possible, therapy should be based on local (regional, farm
level) epidemiological information about susceptibility of the target bacteria.

Revised: September 2022
AN: 01365/2021
Use of the product deviating from the instructions given in the SPC may increase the
prevalence of bacteria resistant to cefapirin and may decrease the effectiveness of
the treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Penicillin and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillin may lead to cross
reactions to cephalosporins and vice versa.
Allergic reactions to these substances are occasionally serious.
1. Do not handle this product if you know you are sensitised or if you have been
advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended
precautions.
3. If you develop symptoms following exposure, such as a skin rash, you should
seek medical advice and show the doctor this warning. Swelling of the face, lips
or eyes or difficulty with breathing are more serious symptoms and require
urgent medical attention.
Gloves should be worn in order to avoid skin contact during preparation and
administration of the product.
Accidental spillage on the skin should be washed off immediately with soap and
water.
Wash hands after use.

Not to be administered concurrently with other intrauterine antibiotic preparations.

Revised: September 2022
AN: 01365/2021

This veterinary medicinal product does not require any special storage conditions
Syringes are for single use only.

Depending on the response, a second treatment 7-14 days later may be required in
some cases if clinical signs persist.
In animals that have been inseminated the product may be used one day after
insemination. In cases of pyometra, pre-treatment with prostaglandin is
recommended in order to induce luteolysis and remove debris from the uterine cavity.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Product supplied as a single dose syringe therefore overdose unlikely to occur.
4.11 Withdrawal period(s)
Meat and offal: 1 day.
Milk: Zero hours.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.