Bimacox 2.5 mg/ml Oral Suspension for Sheep and Cattle

If there is no recent and confirmed history of clinical coccidiosis, the presence of the
disease in the flock or herd must be established before the product is used.
The preferred timing of treatment is directed by the known epidemiology of Eimeria
spp. with treatment being most effective during the pre-patent phase of infection
before clinical signs occur.
Calves: In certain cases, only a transient reduction of oocyst shedding may be
achieved.
Suspected clinical cases of resistance to anticoccidials should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results
of the test(s) strongly suggest resistance to a particular antiprotozoal, an anticoccidial
belonging to another pharmacological class and having a different mode of action
should be used.
Cross-resistance between toltrazuril and diclazuril is possible and should be
investigated. Use of diclazuril should be carefully considered when susceptibility
testing has shown resistance to triazine-derivates because its effectiveness may be
reduced.

Special precautions for safe use in the target species:
Use of the veterinary medicinal product should be based on identification and
susceptibility testing of the target pathogen(s). If this is not possible, therapy should
be based on epidemiological information and knowledge of susceptibility of the target
pathogens at farm level, or at local/regional level.
Use of the veterinary medicinal product should be in accordance with official, national
and regional antimicrobial policies.
Coccidiosis is an indicator of insufficient hygiene in the flock/pen. It is recommended
to improve hygiene and to treat all lambs in a group and all calves in a pen. This will
contribute to reduce the infection pressure and assure a better epidemiological
control of the coccidiosis infection.
To alter the course of an established clinical coccidial infection, in individual animals
already showing signs of diarrhoea, additional supportive fluid therapy is essential.
Preventative use of this veterinary product should be restricted to animals that have
very high risk of infection.
Frequent and repeated use of antiprotozoals may lead to the development of
resistance in the target parasite.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Wash hands after administration of the product.
Special precautions for the protection of the environment:
Not applicable.