ZORABEL 25 mg/ml Solution for Use in Drinking Water for Chickens and Turkeys

Combination of the product with antibiotics may result in reduced water intake in
turkeys. The concomitant administration of other substances to the drinking water
should be avoided.
4.9 Amounts to be administered and administration route
Administration: In drinking water use
The recommended dose rate is 7 mg toltrazuril per kg of body weight (equivalent to
28 ml of medicinal product per 100 kg of body weight) daily given for 2 consecutive
days.
In order to ensure administration of a correct dose, accurately determine the body
weight of the animals.

Revised: October 2024
AN: 01060/2024 & 01296/2024
The treatment is recommended to be given either continuously over 24 h or
alternatively at a treatment duration of 8 hours per day.
For the preparation of medicated water the body weight of the animals to be treated
and their actual daily water consumption should be taken into account. Consumption
may vary depending on factors like species, age, state of health, breed and
husbandry system (e.g. different temperature, different light regimes).
Considering continuous treatment over 24 hours the following calculation should be
made for providing the required amount of veterinary medicinal product in ml per litre
drinking water:
0.28 ml ZORABEL 25
mg/ml per kg bodyweight
per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal (24 hours)
= x ml ZORABEL 25
mg/ml per litre drinking
water
Total demand of ZORABEL 25 mg/ml per day (24 hours):
The calculated volume (x ml ZORABEL 25 mg/ml per litre) should then be multiplied
with the total daily water consumption (l) for the 24 hour period.
Considering a treatment duration of 8 hours per day the following calculation should
be made for providing the required amount of veterinary medicinal product in ml per
litre drinking water:
0.28 ml ZORABEL 25
mg/ml per kg bodyweight
per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal per 8 hours
= x ml ZORABEL 25
mg/ml per litre drinking
water
Total demand of ZORABEL 25 mg/ml for a treatment duration of 8 hours:
The calculated volume (x ml ZORABEL 25 mg/ml per litre) should then be multiplied
with the water consumption (l) for the 8 hour period.
The veterinary medicinal product should be dissolved in drinking water (gentle
mixing) before use.
The use of acidic water may cause precipitation of the active substance at
recommended doses. The solution should be prepared daily.
At doses ranging from 1 ml to 3 ml of the veterinary medicinal product per litre of
drinking water, the solubility is ensured over the treatment period. Dilutions more
concentrated than 3:1,000 (3 ml of product to 1 litre drinking water) may result in
precipitation.
Because of potential solubility issue, the administration via header tanks should be
avoided.
The use of suitably calibrated weighing equipment is recommended if part of
containers is used.
Sufficient access to the system of water supply should be available for the animals to
be treated to ensure adequate water consumption. No other source of drinking water
should be available during the medication period. In free range husbandry systems
animals should be kept in the stable during treatment.

Revised: October 2024
AN: 01060/2024 & 01296/2024
After the end of the medication period the water supply system should be cleaned
appropriately to avoid intake of sub-therapeutic amounts of the active substance.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The first signs of intolerance such as reduced water intake were observed beyond 3-
5 times the recommended dose.
4.11 Withdrawal period(s)
ChickenMeat and offal:18 daysEggs: Not for use in birds producing or intended to
produce eggs for human consumption. Do not use within
6 weeks before the start of the laying period.
TurkeyMeat and offal:16 days
5.