Zolvix 25 mg/ml Oral Solution for Sheep

Unnecessary use of antiparasitics or use deviating from the instructions given
in the SPC may increase the resistance selection pressure and lead to
reduced efficacy. The decision to use the product should be based on
confirmation of the parasitic species and burden, or of the risk of infection
based on its epidemiological features, for each flock.
Repeated use for an extended period, particularly when using the same class
of substances, increases the risk of resistance development. Within a flock,
maintenance of susceptible refugia is essential to reduce that risk.
Systematically applied interval-based treatment and treatment of a whole flock
should be avoided. Instead, if feasible, only selected individual animals or
subgroups should be treated (targeted selective treatment). This should be
combined with appropriate husbandry and pasture management measures.
Guidance for each specific flock should be sought from the responsible
veterinarian.
Isolated cases of resistance against monepantel have been identified within
the European Union.
The use of this product should take into account local information about
susceptibility of the target parasites, where available.
In order to help delay the development of resistance, users are advised to
check the success of the treatment (e.g. clinical appearance, faecal egg
counts). It is recommended to further investigate cases of suspected
resistance, using an appropriate diagnostic method (e.g. Faecal Egg Count
Reduction Test). Where the results of the tests strongly suggest resistance to

Issued: August 2023
AN: 01900/2022
a particular anthelmintic, an anthelmintic belonging to another
pharmacological class and having a different mode of action should be used.
Confirmed resistance should be reported to the marketing authorisation holder
or to the competent authorities.

i) Special precautions for use in animals
The safety has not been established in sheep weighing less than 10 kg or
under 2 weeks of age.
ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Personal protective equipment consisting of gloves should be worn when
handling the veterinary medicinal product.
In case of accidental spillage onto skin or into eyes, wash immediately with
water. Take off any contaminated clothes. In case of accidental ingestion seek
medical advice immediately and show the package leaflet or the label to the
physician.
Do not eat, drink or smoke whilst handling the veterinary medicinal product.
Wash hands and exposed skin after handling the veterinary medicinal
product.
iii) Special precautions for the protection of the environment:
Not applicable