Skip to content
NFA-VPS Over the Counter Companion Animal

Zipyran XL 175 mg/175 mg/525 mg tablets for dogs

Active ingredients: Febantel, Praziquantel, Pyrantel

Form

Tablet

Species

Dogs

Manufacturer

Laboratorios Calier, SA

VMD MA No.

20634/4008

What it's used for

Treatment of flea infestation in dogs (Ctenocephalides felis and C. canis). One treatment provides immediate and persistent flea killing activity for 5 wee...

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Febantel + Praziquantel + Py...

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Zipyran XL 175 mg/175 mg/525 mg tablets for dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Treatment of flea infestation in dogs (Ctenocephalides felis and C. canis). One
treatment provides immediate and persistent flea killing activity for 5 weeks. The
product can be used as part of a treatment strategy for the control of flea allergy
dermatitis (FAD) where this has been previously diagnosed by a veterinarian.
Treatment of tick infestation in dogs (Dermacentor reticulatus, Ixodes ricinus,
Rhipicephalus sanguineus). One treatment provides immediate and persistent tick
killing activity for one month.
Fleas and ticks must attach to the host and commence feeding in order to be
exposed to the active substance.
Dosage: the recommended dose is 5 mg of Praziquantel, 5 mg of Pyrantel
(embonate) and 15 mg of Febantel per kg of body weight (equivalent to one tablet/35
kg bw) in accordance with the following table:
Animal Body weight
(kg)
Nº of tablets
17.5½> 17.5 - 351
AN: 03750/2024 & 03753/2024
> 35 – 52.51 ½> 52.5 – 702
To ensure a correct dosagee, body weight should be determined as accurately as
possible.
For single oral treatment only.
The tablets are administered by placing whole and/or divided tablets at the back of
the tongue for forced swallowing.
In cases of confirmed single infestation by cestodes or nematodes, a monovalent
veterinary medicinal product containing a cestocide or a nematocide alone should be
used.
See section ”Use during pregnancy, lactation or lay”.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Dogs:
Very rare
(<1 animal / 10 000 animals
treated, including isolated
reports):
Anorexia
Lethargy
Gastrointestinal disturbances (diarrhoea and
vomiting)
Hyperactivity
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class.
Fleas serve as intermediate hosts and source of infection for one common type of
tapeworm – .
Tapeworm infestation may reoccur unless control of intermediate hosts as well as the
environment is undertaken concurrently to the treatment.

Special precautions for safe use in the target species:
In debilitated or heavily infested animals, the veterinary medicinal product should be
used only after evaluation of the risk / benefit by the veterinarian
Digestive haemorrhages (diarrhoea, bloody stools and even deaths) provoked by
worm lysis may result from anthelminthic treatment in cases of heavy infestations.
In dogs less than 6 weeks old, tapeworm infections are highly uncommon. Treatment
of animals less than 6 weeks old with a fixed combination veterinary medicinal
product against cestodes and nematodes may, therefore, not be necessary.
The active substances are not known to cause particular adverse effects in young
animals. Nevertheless the safety of the formulation has not been established in dogs
less than 5 months of age.
Roundworm and hookworm infections: In some animals, and
Toxocara canis may not be eradicated by the treatment, resulting in a continued risk
of egg shedding into the environment. Follow-up examinations of the faeces are
advisable and according to the results of these examinations, treatment with a
nematocidal veterinary medicinal product may be carried out, if necessary.
To minimise the risk of re-infestation and new infestation, excreta should be collected
and properly disposed out of for 24 hours following treatment
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental ingestion, seek medical advice and show the package leaflet to
the physician.
In case of accidental contact wash hands thoroughly
People with known hypersensitivity to any of the ingredients should avoid contact
with the veterinary medicinal product.
Wash hands after use.
AN: 03750/2024 & 03753/2024
Special precautions for the protection of the environment:
Not applicable.
Do not use simultaneously with piperazine, as the anthelmintic effects of pyrantel and
piperazine may be antagonized.
Plasma concentrations of praziquantel may be decreased by concomitant
administration with drugs that increase the activity of cytochrome P-450 enzymes
(e.g. dexamethasone, phenobarbital).
Concurrent use with other cholinergic compounds can lead to toxicity.
This veterinary medicinal product does not require any special storage conditions.
Not applicable.
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

Medication costs adding up?

Pet insurance can cover prescription medications. Find the right policy for your pet.

Compare insurance

Related Conditions

Find cheaper vets near you

Compare vet consultation prices in your area. Save on procedures and get a prescription to buy medications online.