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NFA-VPS Over the Counter Companion Animal

Zipyran 50 mg/50 mg/150 mg Tablets for Dogs

Active ingredients: Febantel, Praziquantel, Pyrantel

Form

Tablet

Species

Dogs

Manufacturer

Laboratorios Calier, SA

VMD MA No.

20634/4004

What it's used for

Treatment of flea infestation in dogs (Ctenocephalides felis and C. canis). One treatment provides immediate and persistent flea killing activity for 5 wee...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Clinical information

Zipyran 50 mg/50 mg/150 mg Tablets for Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Treatment of flea infestation in dogs (Ctenocephalides felis and C. canis). One
treatment provides immediate and persistent flea killing activity for 5 weeks. The
product can be used as part of a treatment strategy for the control of flea allergy
dermatitis (FAD) where this has been previously diagnosed by a veterinarian.
Treatment of tick infestation in dogs (Dermacentor reticulatus, Ixodes ricinus,
Rhipicephalus sanguineus). One treatment provides immediate and persistent tick
killing activity for one month.
Fleas and ticks must attach to the host and commence feeding in order to be
exposed to the active substance.
Dosage: the recommended dose is 5 mg of Praziquantel, 5 mg of Pyrantel (embonate) and
15 mg of Febantel per kg of body weight (equivalent to one tablet/10 kg bw) in accordance
with the following table:
Animal Body weight
(kg)
Nº of tablets
2.5 – 5½5 – 10110 – 151 ½
AN: 03750/2024 & 03753/2024
15 – 20220 – 252 ½25 – 303
To ensure a correct dosage, body weight should be determined as accurately as possible.
For single oral treatment only.
The tablets are administered by placing whole and/or divided tablets at the back of the
tongue for forced swallowing.
To further improve accuracy of dosing, tablets may be quartered.
In cases of confirmed single infestation by cestodes or nematodes, a monovalent
veterinary medicinal product containing a cestocide or a nematocide alone should be
used.
See section ”Use during pregnancy, lactation or lay”.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Dogs:
Very rare
(<1 animal / 10 000 animals
treated, including isolated
reports):
Anorexia
Lethargy
Gastrointestinal disturbances (diarrhoea and vomiting)
Hyperactivity
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Parasite resistance to any particular class of anthelmintic may develop following frequent,
repeated use of an anthelmintic of that class.
Fleas serve as intermediate hosts and source of infection for one common type of
tapeworm – .
Tapeworm infestation may reoccur unless control of intermediate hosts as well as the
environment is undertaken concurrently to the treatment.

Special precautions for safe use in the target species:
In debilitated or heavily infested animals, the veterinary medicinal product should be used
only after evaluation of the risk / benefit by the veterinarian
Digestive haemorrhages (diarrhoea, bloody stools and even deaths) provoked by worm
lysis may result from anthelminthic treatment in cases of heavy infestations.
In dogs less than 6 weeks old, tapeworm infections are highly uncommon. Treatment of
animals less than 6 weeks old with a fixed combination veterinary medicinal product
against cestodes and nematodes may, therefore, not be necessary.
The active substances are not known to cause particular adverse effects in young animals.
Nevertheless the safety of the formulation has not been established in dogs less than 5
months of age.
Roundworm and hookworm infections: In some animals, and
Toxocara canis may not be eradicated by the treatment, resulting in a continued risk of
egg shedding into the environment. Follow-up examinations of the faeces are advisable
and according to the results of these examinations, treatment with a nematocidal
veterinary medicinal product may be carried out, if necessary.
To minimise the risk of re-infestation and new infestation, excreta should be collected and
properly disposed out of for 24 hours following treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental ingestion, seek medical advice and show the package leaflet to the
physician.
In case of accidental contact wash hands thoroughly
People with known hypersensitivity to any of the ingredients should avoid contact with the
veterinary medicinal product.
Wash hands after use.
AN: 03750/2024 & 03753/2024
Special precautions for the protection of the environment:
Not applicable.
Do not use simultaneously with piperazine, as the anthelmintic effects of pyrantel and
piperazine may be antagonized.
Plasma concentrations of praziquantel may be decreased by concomitant administration
with drugs that increase the activity of cytochrome P-450 enzymes (e.g. dexamethasone,
phenobarbital).
Concurrent use with other cholinergic compounds can lead to toxicity.
This veterinary medicinal product does not require any special storage conditions.
Not applicable.
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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