Vetmedin 10 mg Chewable Tablets for Dogs

Monitoring of cardiac function and morphology is recommended in animals treated
with pimobendan.
(See also section 4.6).
The chewable tablets are flavoured. In order to avoid any accidental ingestion, store
tablets out of reach of the animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician.
Wash hands after use.
Advice to doctors: accidental ingestion, especially by a child, may lead to the
occurrence of tachycardia, orthostatic hypotension, flushing of the face and
headaches.
Close bottle tightly with cap directly after removal of the required number of tablets.

Revised: March 2024
Divergence from NI MA following AN: 00447/2023Page 3 of 7
4.6 Adverse reactions (frequency and seriousness)
In rare cases a slight positively chronotropic effect (rise in heart rate) and vomiting
can occur. However, these effects are dose-dependent and can be avoided by
reducing the dose.
In rare cases transient diarrhoea, anorexia or lethargy have been observed.
Although a relationship with pimobendan has not been clearly established, in very
rare cases, signs of effects on primary haemostasis (petechiae on mucous
membranes, subcutaneous haemorrhages) may be observed during treatment.
These signs disappear when the treatment is withdrawn. In rare cases, an increase in
mitral valve regurgitation has been observed during chronic pimobendan treatment in
dogs with mitral valve disease.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reactions)
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated
reports).
4.7 Use during pregnancy, lactation or lay
Laboratory studies in rats and rabbits have not produced any evidence of teratogenic
or foetotoxic effects. However, these studies have shown evidence of maternotoxic
and embryotoxic effects at high doses, and have also shown that pimobendan is
excreted into milk. The safety of the product has not been assessed in pregnant or
nursing bitches. Use only according to the benefit/risk assessment by the responsible
veterinarian.
4.8 Interaction with other medicinal products and other forms of interaction
In