Vetergesic Multidose, 0.3mg/ml, Solution for Injection for Dogs and Cats
Active ingredient: Buprenorphine
Form
Injection
Species
Manufacturer
Ceva Sante Animale
VMD MA No.
14966/5029
What it's used for
DOG Post-operative analgesia. Potentiation of the sedative effects of centrally-acting agents. CAT Post-operative analgesia
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Vetergesic Multidose, 0.3mg/ml, Solution for Injection for Dogs and Cats — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
Post-operative analgesia.
Potentiation of the sedative effects of centrally-acting agents.
CAT
Post-operative analgesia
Do not use pre-operatively for Caesarian section (see Section 4.7).
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Revised: September 2025
AN: 01877/2025
Rare
(1 to 10 animals / 10,000 animals
treated):
Hypertension, TachycardiaVery rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Injection site pain, Injection site irritation VocalisationUndetermined frequency (cannot be
estimated from the available data):
Increased salivation Bradycardia
Hypothermia, Dehydration
Agitation
Miosis
Respiratory distress
Cats:
Common
(1 to 10 animals / 100 animals treated):
Behavioural disorder NOS
(excessive purring),
Pacing
Rubbing
Mydriasis
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Injection site pain, Injection site irritation VocalisationUndetermined frequency (cannot be
estimated from the available data):
Respiratory distress
usually resolve within 24 hours.
When administered for analgesia sedation occurs rarely but may appear at higher
dosages.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or the national competent authority via
the national reporting system. See the package leaflet for respective contact details.
Special precautions for use in animals
Buprenorphine may cause respiratory depression and as with other opioid drugs,
care should be taken when treating animals with impaired respiratory function or
animals that are receiving drugs that can cause respiratory depression.
In case of renal, cardiac or hepatic dysfunction or shock, there may be greater risk
associated with the use of the product. The benefit: risk assessment for using the
product should be made by the attending veterinarian. Safety has not been fully
evaluated in clinically compromised cats.
Buprenorphine should be used with caution in animals with impaired liver function,
especially biliary tract disease, as the substance is metabolised by the liver and its
intensity and duration of action may be affected in such animals.
The safety of buprenorphine has not been demonstrated in animals less than 7
weeks of age, therefore, use in such animals should be based on the risk: benefit
assessment of the veterinarian.
Repeat administration earlier than the recommended repeat interval suggested in
Section 34.9 is not recommended.
Long-term safety of buprenorphine in cats has not been investigated beyond 5
consecutive days of administration.
The effect of an opioid on head injury is dependent on the type and severity of the
injury and the respiratory support supplied. The product should be used in
accordance with the benefit:risk assessment of the attending veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Wash hands/affected area thoroughly after any accidental spillage.
As buprenorphine has opioid-like activity, care should be taken to avoid self-
injection. In case of accidental self-injection or ingestion, seek medical advice
immediately and show the package leaflet or the label to the physician.
Following eye contamination or skin contact, wash thoroughly with cold running
water. Seek medical advice if irritation persists.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable
Revised: September 2025
AN: 01877/2025
centrally- acting agents, including tranquillisers, sedatives and hypnotics.
There is evidence in humans to indicate that therapeutic doses of buprenorphine do
not reduce the analgesic efficacy of standard doses of an opioid agonist, and that
when buprenorphine is employed within the normal therapeutic range, standard
doses of opioid agonist may be administered before the effects of the former have
ended without compromising analgesia. However, it is recommended that
buprenorphine is not used in conjunction with morphine or other opioid-type
analgesics, e.g. etorphine, fentanyl, pethidine, methadone, papaveretum or
butorphanol.
Buprenorphine has been used with acepromazine, alphaxalone/alphadalone,
atropine, dexmedetomidine, halothane, isoflurane, ketamine, medetomidine,
propofol, sevoflurane, thiopentone and xylazine. When used in combination with
sedatives, depressive effects on heart rate and respiration may be augmented.
Shake well before use.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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