POM-V Prescription Required

Tranquinervin 10 mg/ml Solution for Injection for Horses

Active ingredient: Acepromazine

Form

Injection

Species

Horses

Manufacturer

Le Vet Beheer B.V.

VMD MA No.

41821/4054

What it's used for

Tranquilisation: Acepromazine tranquilisation (ataraxy) involves a modification of temperament which is not associated with hypnosis, narcosis or marked se...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Acepromazine

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Tranquinervin 10 mg/ml Solution for Injection for Horses — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Tranquilisation: Acepromazine tranquilisation (ataraxy) involves a modification of
temperament which is not associated with hypnosis, narcosis or marked sedation. This is
achieved with low doses of acepromazine. At low doses, acepromazine reduces anxiety
which is beneficial for use in horses prior to shoeing or transportation.
Sedation: At higher dose rates acepromazine is an effective sedative, as an adjunct to,
or replacement for, physical restraint e.g. dentistry, handling and shoeing. The relaxant
effects aid examination of the penis in horses and the treatment of tetanus and choke.
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injection is made slowly.
0.03−0.10
medicinal product per 50 kg bodyweight.
To ensure a correct dosage, body weight should be determined as accurately as possible.
Normally, single doses of acepromazine are administered. Long term use is not
recommended. On the rare occasions that repeat dosing is required, the dosing interval
should be 36−48 hours.
Take adequate precautions to maintain sterility. Avoid the introduction of contamination
during use. Should any apparent growth or discolouration occur, discard the veterinary
medicinal product.
The maximum number of vial punctures when using needle sizes of 21G and 23G should
not exceed 100 and when using a 18G needle, the maximum should not exceed 40.

Do not use in pregnant mares.
Do not use in animals in existing severe emotional excitation.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Do not administer to breeding stallions. See section 3.6.

Horses:
Very common
(>1 animal / 10 animals treated):
Decreased haematocrit
Penile prolapse
a,c
Common
(1 to 10 animals / 100 animals
treated):
HypotensionUncommon
(1 to 10 animals / 1,000 animals
treated):
Paraphimosis
b,c
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Penile disorder
b,c
Convulsion
d
Death
d
Undetermined frequency
(cannot be estimated from the
available data)
Priapism
b,c
Disorientation
d
a
Reversible paralysis of the retractor penis muscle.
b
Paraphimosis can sometimes occur as a sequel to priapism, however this only very
rarely results in
permanent penile dysfunction.
c
When extrusion of the penis occurs, the owner should be advised to inform his veterinary
surgeon if retraction of the penis does not take place within hours. Suitable
treatments have been described in the veterinary literature e.g. manual compression
during the period of general anaesthesia, penile support and manual compression, use
of an Esmarch bandage, or drug reversal (e.g. slow intravenous administration of
benztropine mesylate).
d
Can occur after accidental intracarotid injection.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Acepromazine has little, if any, analgesic effect so that painful procedures must be
avoided, particularly where animals are known to have unpredictable temperaments.
Therefore, the usual precautions should be maintained when handling sedated horses.
During sedation, horses will normally retain visual and auditory acuity, so that loud sounds
and rapid movements may cause arousal from the sedated state. It is therefore important
to keep treated horses in a quiet environment and avoid sensory stimulation as far as
possible.

Special precautions for safe use in the target species:
Situations may arise where general anaesthesia is required in the hours following
use of the veterinary medicinal product. In such cases care should be taken to reduce the
dose of other premedicants and anaesthetic agents, particularly parenteral barbiturates,
so as to avoid potentiation and additive depressant effects.
When administered to male horses (geldings or non-breeding stallions), use the lowest
dose recommended to produce the required effect.
Acepromazine may cause hypothermia due to depression of the thermoregulatory centre
and peripheral vasodilation.
Acepromazine is an adrenoceptor blocking drug and this causes hypotension and
lowered haematocrit. The veterinary medicinal product should therefore be administered
with great caution, and at low dose rates only to debilitated horses and animals in states
of hypovolaemia, anaemia and shock, or with cardiovascular disease. Rehydration should
precede acepromazine administration.
Duration of action may be prolonged and this should be remembered when riding, as
acepromazine may affect performance and appear in drug tests for some time.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This veterinary medicinal product contains a potent sedative; care should be taken, when
handling and administering the veterinary medicinal product, to avoid accidental self-
exposure.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician but DO NOT DRIVE as sedation and changes
in blood pressure may occur. Symptomatic treatment may be required.
If accidental eye contamination occurs, flush gently with fresh running water for 15
minutes. Medical advice should be sought if irritation persists.
In the event of accidental skin contamination, contaminated clothing should be removed
and the area washed with large amounts of soap and water. Medical advice should be
sought if irritation persists.
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Wash hands and exposed skin thoroughly after use.
Special precautions for the protection of the environment:
Not applicable.

Phenothiazines are additive to the actions of other CNS depressants and will potentiate
general anaesthesia (see section 3.2, indications for use).
Do not use this veterinary medicinal product in conjunction with organophosphates and/or
procaine hydrochloride, as it may enhance activity and potential toxicity.

Keep the vial in the outer carton in order to protect from light.

The veterinary medicinal product is not authorised for use in horses intended for human
consumption.
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This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.