Tramazole 100 mg/ml Oral Suspension for Cattle and Sheep

Cattle suffering from severe lung damage due to heavy lungworm infestation may
continue to cough for some weeks after infection.
Care should be taken to avoid the following practices because they increase the risk of
development of resistance and could ultimately result in ineffective therapy:
• Too frequent and repeated use of anthelmintics from the same class, over an extended
period of time.
• Underdosing, which may be due to underestimation of bodyweight, misadministration
of the product, or lack of calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the
test(s) strongly suggest resistance to a particular anthelmintic belonging to another
pharmacological class and having a different mode of action should be used.
Resistance to benzimidazoles (which includes albendazole) has been reported in
Teladorsagia
in a number of countries, including the EU. Resistance to albendazole has been reported
in
Zealand. Therefore the use of this product should be based on local (regional, farm)
epidemiological information about susceptibility of nematodes and recommendations on
how to limit further selection for resistance to anthelmintics.

Special precautions for safe use in the target species:
Care must be taken not to damage the pharyngeal region when dosing, particularly in
sheep. Not to be diluted or mixed with other products. Avoid the introduction of
contamination during use. Intensive use or misuse of anthelmintics can give rise to
resistance. To reduce this risk dosing programmes should be discussed with your
veterinary surgeon.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product can cause skin and eye irritation.
Personal protective equipment consisting of suitable protective clothing, including
impermeable rubber gloves, should be worn when handling the veterinary medicinal
product.
In case of accidental spillage onto skin, wash the affected area with soap and water. If
irritation persists seek medical advice immediately and show the package leaflet or the
label to the physician.
In case of accidental eye exposure, flush eye thoroughly with running water. If irritation
persists seek medical advice immediately and show the package leaflet or the label to the
physician.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.