POM-V
Prescription Required
TOLTRA-K 25 mg/ml Solution for Use in Drinking Water for Chickens and Turkeys
Active ingredient: Toltrazuril
Form
Solution
Species
Chickens
Turkeys
Manufacturer
Laboratorios Karizoo S.A
VMD MA No.
31223/5000
What it's used for
For the treatment of coccidiosis caused by: Chicken (pullets and chickens for reproduction): maxima, E. necatrix and E. tenella. Turkey: Eimeria adenoides,...
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Clinical information
TOLTRA-K 25 mg/ml Solution for Use in Drinking Water for Chickens and Turkeys — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
For the treatment of coccidiosis caused by:
Chicken (pullets and chickens for reproduction):
maxima, E. necatrix and E. tenella.
Turkey: Eimeria adenoides, E. meleagrimitis.
Chicken (pullets and chickens for reproduction):
maxima, E. necatrix and E. tenella.
Turkey: Eimeria adenoides, E. meleagrimitis.
In drinkwing water use
The recommended dose rate is 7 mg toltrazuril per kg of body weight (equivalent to
28 ml of medicinal product per 100 kg of body weight) daily given for 2 consecutive
days
The treatment is recommended to be given either continuously over 24 h or
alternatively at a treatment duration of 8 hours per day.
To ensure a correct dosage, body weight should be determined as accurately as
possible..
The intake of medicated water depends on the clinical condition of the animals. In
order to obtain the correct dosage, the concentration of toltrazuril may need to be
adjusted accordingly.
Considering continuous treatment over 24 hours the following calculation should be
made for providing the required amount of veterinary medicinal product in ml per litre
drinking water:
0.28 ml veterinary
medicinal product per kg
bodyweight per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal (24 hours)
= x ml veterinary
medicinal product per
litre drinking water
Total demand of veterinary medicinal product per day (24 hours):
The calculated volume (x ml veterinary medicinal product per litre) should then be
multiplied with the total daily water consumption (l) for the 24 hour period.
Considering a treatment duration of 8 hours per day the following calculation should
be made for providing the required amount of veterinary medicinal product in ml per
litre drinking water:
0.28 ml veterinary
medicinal product per kg
bodyweight per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal per 8 hours
= x ml veterinary
medicinal product per
litre drinking water
Total demand of veterinary medicinal product for a treatment duration of 8 hours:
The calculated volume (x ml veterinary medicinal product per litre) should then be
multiplied with the water consumption (l) for the 8 hour period.
The veterinary medicinal product should be dissolved in drinking water (gentle
mixing) before use.
The use of acidic water may cause precipitation of the active substance at
recommended doses. The solution should be prepared daily.
Revised: June 2024
AN: 02357/2023Page 4 of 6
At doses ranging from 1 ml to 3 ml of the veterinary medicinal product per litre of
drinking water, the solubility is ensured over the treatment period. Dilutions more
concentrated than 3:1,000 (3 ml of product to 1 litre drinking water) may result in
precipitation.
Because of potential solubility issue, the administration via header tanks should be
avoided.
The use of suitably calibrated weighing equipment is recommended if part of
containers is used.
Sufficient access to the system of water supply should be available for the animals to
be treated to ensure adequate water consumption. No other source of drinking water
should be available during the medication period. In free range husbandry systems
animals should be kept in the stable during treatment.
After the end of the medication period the water supply system should be cleaned
appropriately to avoid intake of sub-therapeutic amounts of the active substance.
The recommended dose rate is 7 mg toltrazuril per kg of body weight (equivalent to
28 ml of medicinal product per 100 kg of body weight) daily given for 2 consecutive
days
The treatment is recommended to be given either continuously over 24 h or
alternatively at a treatment duration of 8 hours per day.
To ensure a correct dosage, body weight should be determined as accurately as
possible..
The intake of medicated water depends on the clinical condition of the animals. In
order to obtain the correct dosage, the concentration of toltrazuril may need to be
adjusted accordingly.
Considering continuous treatment over 24 hours the following calculation should be
made for providing the required amount of veterinary medicinal product in ml per litre
drinking water:
0.28 ml veterinary
medicinal product per kg
bodyweight per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal (24 hours)
= x ml veterinary
medicinal product per
litre drinking water
Total demand of veterinary medicinal product per day (24 hours):
The calculated volume (x ml veterinary medicinal product per litre) should then be
multiplied with the total daily water consumption (l) for the 24 hour period.
Considering a treatment duration of 8 hours per day the following calculation should
be made for providing the required amount of veterinary medicinal product in ml per
litre drinking water:
0.28 ml veterinary
medicinal product per kg
bodyweight per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal per 8 hours
= x ml veterinary
medicinal product per
litre drinking water
Total demand of veterinary medicinal product for a treatment duration of 8 hours:
The calculated volume (x ml veterinary medicinal product per litre) should then be
multiplied with the water consumption (l) for the 8 hour period.
The veterinary medicinal product should be dissolved in drinking water (gentle
mixing) before use.
The use of acidic water may cause precipitation of the active substance at
recommended doses. The solution should be prepared daily.
Revised: June 2024
AN: 02357/2023Page 4 of 6
At doses ranging from 1 ml to 3 ml of the veterinary medicinal product per litre of
drinking water, the solubility is ensured over the treatment period. Dilutions more
concentrated than 3:1,000 (3 ml of product to 1 litre drinking water) may result in
precipitation.
Because of potential solubility issue, the administration via header tanks should be
avoided.
The use of suitably calibrated weighing equipment is recommended if part of
containers is used.
Sufficient access to the system of water supply should be available for the animals to
be treated to ensure adequate water consumption. No other source of drinking water
should be available during the medication period. In free range husbandry systems
animals should be kept in the stable during treatment.
After the end of the medication period the water supply system should be cleaned
appropriately to avoid intake of sub-therapeutic amounts of the active substance.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
excipients.
Chicken (pullets and chickens for reproduction) and turkey: None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Hygiene measures help to reduce the risk of coccidiosis. It is therefore recommended
that attention be paid during treatment to hygiene in confinement buildings,
particularly in terms of general cleanliness and moisture reduction.
It is recommended to treat all animals in a pen. For best results, treatment should be
initiated before the clinical signs of disease have spread throughout the whole group.
Revised: June 2024
AN: 02357/2023Page 2 of 6
Special precautions for use in animals
The veterinary medicinal product is a strongly alkaline solution and should not be
administered undiluted.
As with any antiparasiticide, frequent and prolonged use of an antiprotozoal of the
same class of active substance and underdosing due to underestimation of the live
weight may result in the development of resistances.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This veterinary medicinal product is an alkaline solution-contact with skin and
mucous membranes should be avoided. Personal protective equipment consisting of
gloves and goggles should be worn when handling this product. Wash any splashes
from skin or eyes immediately with water. In case of irritation of eyes or skin after
exposure, seek medical advice immediately and show the package leaflet or the label
to the physician.
People with known sensitivity to toltrazuril, or any excipient, should avoid contact with
this product.
Do not eat, drink or smoke while handling the product.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
Other precautions
Not applicable
that attention be paid during treatment to hygiene in confinement buildings,
particularly in terms of general cleanliness and moisture reduction.
It is recommended to treat all animals in a pen. For best results, treatment should be
initiated before the clinical signs of disease have spread throughout the whole group.
Revised: June 2024
AN: 02357/2023Page 2 of 6
Special precautions for use in animals
The veterinary medicinal product is a strongly alkaline solution and should not be
administered undiluted.
As with any antiparasiticide, frequent and prolonged use of an antiprotozoal of the
same class of active substance and underdosing due to underestimation of the live
weight may result in the development of resistances.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This veterinary medicinal product is an alkaline solution-contact with skin and
mucous membranes should be avoided. Personal protective equipment consisting of
gloves and goggles should be worn when handling this product. Wash any splashes
from skin or eyes immediately with water. In case of irritation of eyes or skin after
exposure, seek medical advice immediately and show the package leaflet or the label
to the physician.
People with known sensitivity to toltrazuril, or any excipient, should avoid contact with
this product.
Do not eat, drink or smoke while handling the product.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
Other precautions
Not applicable
Combination of the product with antibiotics may result in reduced water intake in
turkeys. The concomitant administration of other substances to the drinking water
should be avoided.
turkeys. The concomitant administration of other substances to the drinking water
should be avoided.
Do not store above 30ºC.
Revised: June 2024
AN: 02357/2023Page 3 of 6
4.8 Interaction with other medicinal products and other forms of interaction
Combination of the product with antibiotics may result in reduced water intake in
turkeys. The concomitant administration of other substances to the drinking water
should be avoided.
4.9 Amounts to be administered and administration route
In drinkwing water use
The recommended dose rate is 7 mg toltrazuril per kg of body weight (equivalent to
28 ml of medicinal product per 100 kg of body weight) daily given for 2 consecutive
days
The treatment is recommended to be given either continuously over 24 h or
alternatively at a treatment duration of 8 hours per day.
To ensure a correct dosage, body weight should be determined as accurately as
possible..
The intake of medicated water depends on the clinical condition of the animals. In
order to obtain the correct dosage, the concentration of toltrazuril may need to be
adjusted accordingly.
Considering continuous treatment over 24 hours the following calculation should be
made for providing the required amount of veterinary medicinal product in ml per litre
drinking water:
0.28 ml veterinary
medicinal product per kg
bodyweight per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal (24 hours)
= x ml veterinary
medicinal product per
litre drinking water
Total demand of veterinary medicinal product per day (24 hours):
The calculated volume (x ml veterinary medicinal product per litre) should then be
multiplied with the total daily water consumption (l) for the 24 hour period.
Considering a treatment duration of 8 hours per day the following calculation should
be made for providing the required amount of veterinary medicinal product in ml per
litre drinking water:
0.28 ml veterinary
medicinal product per kg
bodyweight per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal per 8 hours
= x ml veterinary
medicinal product per
litre drinking water
Total demand of veterinary medicinal product for a treatment duration of 8 hours:
The calculated volume (x ml veterinary medicinal product per litre) should then be
multiplied with the water consumption (l) for the 8 hour period.
The veterinary medicinal product should be dissolved in drinking water (gentle
mixing) before use.
The use of acidic water may cause precipitation of the active substance at
recommended doses. The solution should be prepared daily.
Revised: June 2024
AN: 02357/2023Page 4 of 6
At doses ranging from 1 ml to 3 ml of the veterinary medicinal product per litre of
drinking water, the solubility is ensured over the treatment period. Dilutions more
concentrated than 3:1,000 (3 ml of product to 1 litre drinking water) may result in
precipitation.
Because of potential solubility issue, the administration via header tanks should be
avoided.
The use of suitably calibrated weighing equipment is recommended if part of
containers is used.
Sufficient access to the system of water supply should be available for the animals to
be treated to ensure adequate water consumption. No other source of drinking water
should be available during the medication period. In free range husbandry systems
animals should be kept in the stable during treatment.
After the end of the medication period the water supply system should be cleaned
appropriately to avoid intake of sub-therapeutic amounts of the active substance.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The first signs of intolerance such as reduced water intake were observed beyond 3-
5 times the recommended dose.
4.11 Withdrawal period(s)
ChickenMeat and offal:18 daysNot for use in birds producing or intended to produce
eggs for human consumption. Do not use within 6 weeks
before the start of the laying period.
TurkeyMeat and offal:16 days
5.
AN: 02357/2023Page 3 of 6
4.8 Interaction with other medicinal products and other forms of interaction
Combination of the product with antibiotics may result in reduced water intake in
turkeys. The concomitant administration of other substances to the drinking water
should be avoided.
4.9 Amounts to be administered and administration route
In drinkwing water use
The recommended dose rate is 7 mg toltrazuril per kg of body weight (equivalent to
28 ml of medicinal product per 100 kg of body weight) daily given for 2 consecutive
days
The treatment is recommended to be given either continuously over 24 h or
alternatively at a treatment duration of 8 hours per day.
To ensure a correct dosage, body weight should be determined as accurately as
possible..
The intake of medicated water depends on the clinical condition of the animals. In
order to obtain the correct dosage, the concentration of toltrazuril may need to be
adjusted accordingly.
Considering continuous treatment over 24 hours the following calculation should be
made for providing the required amount of veterinary medicinal product in ml per litre
drinking water:
0.28 ml veterinary
medicinal product per kg
bodyweight per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal (24 hours)
= x ml veterinary
medicinal product per
litre drinking water
Total demand of veterinary medicinal product per day (24 hours):
The calculated volume (x ml veterinary medicinal product per litre) should then be
multiplied with the total daily water consumption (l) for the 24 hour period.
Considering a treatment duration of 8 hours per day the following calculation should
be made for providing the required amount of veterinary medicinal product in ml per
litre drinking water:
0.28 ml veterinary
medicinal product per kg
bodyweight per day
X
mean body weight (kg)
of animals to be treated
mean water consumption (l) per animal per 8 hours
= x ml veterinary
medicinal product per
litre drinking water
Total demand of veterinary medicinal product for a treatment duration of 8 hours:
The calculated volume (x ml veterinary medicinal product per litre) should then be
multiplied with the water consumption (l) for the 8 hour period.
The veterinary medicinal product should be dissolved in drinking water (gentle
mixing) before use.
The use of acidic water may cause precipitation of the active substance at
recommended doses. The solution should be prepared daily.
Revised: June 2024
AN: 02357/2023Page 4 of 6
At doses ranging from 1 ml to 3 ml of the veterinary medicinal product per litre of
drinking water, the solubility is ensured over the treatment period. Dilutions more
concentrated than 3:1,000 (3 ml of product to 1 litre drinking water) may result in
precipitation.
Because of potential solubility issue, the administration via header tanks should be
avoided.
The use of suitably calibrated weighing equipment is recommended if part of
containers is used.
Sufficient access to the system of water supply should be available for the animals to
be treated to ensure adequate water consumption. No other source of drinking water
should be available during the medication period. In free range husbandry systems
animals should be kept in the stable during treatment.
After the end of the medication period the water supply system should be cleaned
appropriately to avoid intake of sub-therapeutic amounts of the active substance.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The first signs of intolerance such as reduced water intake were observed beyond 3-
5 times the recommended dose.
4.11 Withdrawal period(s)
ChickenMeat and offal:18 daysNot for use in birds producing or intended to produce
eggs for human consumption. Do not use within 6 weeks
before the start of the laying period.
TurkeyMeat and offal:16 days
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Same active ingredient
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