POM-V Prescription Required Companion Animal

Solupam 5 mg/ml Solution for Injection for Dogs and Cats

Active ingredient: Diazepam

Form

Injection

Species

Cats Dogs

Manufacturer

Dechra Regulatory BV

VMD MA No.

50406/3001

What it's used for

As part of a pre-anaesthetic or sedation protocol.

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Diazepam

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Solupam 5 mg/ml Solution for Injection for Dogs and Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

As part of a pre-anaesthetic or sedation protocol.

For slow intravenous injection only.
Short term management of convulsive disorders: 0.5-1.0 mg diazepam/kg
bodyweight (equivalent to 0.5-1.0 ml/5kg). Administered as a slow bolus and
repeated up to three times, after no less than 10 minutes each time.
Short term management of skeletal muscle spasm: 0.5-2.0 mg/kg bodyweight
(equivalent to 0.5-2.0 ml/5kg).
As part of sedation protocol: 0.2-0.6 mg/kg bodyweight (equivalent to 0.2-0.6 ml/5kg).
As part of pre-anaesthesia protocol: 0.1-0.2 mg/kg bodyweight (equivalent to 0.1-0.2
ml/5kg).
The vial may be safely punctured up to 100 times.

Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use in cases of severe hepatic disease.

Rare
(1 to 10 animals / 10,000 animals
treated):
Paradoxical effects (e.g. excitation, aggression,
disinhibiting effect)
a
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hepatic necrosis (acute)
b
, liver failure
b
Undetermined frequencyHypotension
c
, cardiac disorders
c
,
thrombophlebitis
c
Ataxia, disorientation, changes in mentation and
behaviour
Increased appetite
d
a
Mainly in small breeds of dogs.
b
In cats only.
c
May be caused by rapid intravenous administration.
d
Mainly in cats.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See also section “Contact
details” of the package leaflet.

Diazepam alone is less likely to be effective as a sedative when used in animals that
are already excited.
Diazepam can cause sedation and disorientation and should be used with caution in
working animals, such as military, police or service dogs.

Special precautions for safe use in the target species:
The product should be used with caution in animals with hepatic or renal disease and
in debilitated, dehydrated, anaemic, obese, or geriatric animals.
The product should be used with caution in animals in shock, coma, or with significant
respiratory depression.
The product should be used with caution in animals affected by glaucoma.
It is not recommended to use diazepam for convulsive disorder control in cats in case
of chronic poisoning by pesticides (chlorpyrifos) as the toxicity of these
organophosphates may be potentiated.
Paradoxical reactions (including excitation, a disinhibiting effect and aggression) may
be observed if diazepam is used as a sole agent, therefore avoid the use of
diazepam alone in potentially aggressive animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Diazepam is a CNS depressant and can cause sedation and induction of sleep. Care
should be taken to avoid self-injection. In case of accidental self-injection, seek
medical advice immediately and show the package leaflet to the physician, but DO
NOT DRIVE as sedation and impaired muscular function may occur.
Diazepam and its metabolites may be harmful for the unborn child, and are secreted
into breastmilk in small amounts, thereby exerting a pharmacological effect on the
nursing neonate. Pregnant women or women intending to become pregnant and
breastfeeding women should, therefore, avoid handling or take great care when
handling this product and, in the event of exposure, seek medical advice
immediately.
People with known hypersensitivity to diazepam or the excipients should avoid
contact with the veterinary medicinal product.
This product contains benzyl alcohol and can cause skin irritation. Avoid contact with
skin. In the case of contact with skin, wash with soap and water. If irritation persists,
seek medical advice. Wash hands after use.
The product can cause eye irritation. Avoid contact with eyes. If the product comes
into contact with the eyes, rinse the eyes immediately with plenty of water and seek
medical attention if irritation persists.
Special precautions for the protection of the environment:
Not applicable.

Diazepam is a central nervous system depressant which may potentiate the action of
other central nervous system depressants such as barbiturates, tranquilizers,
narcotics and antidepressants.
Diazepam may increase the action of digoxin.
Cimetidine, erythromycin, azole substances (such as itraconazole or ketoconazole)
valproic acid and propanol may slow the metabolism of diazepam. The dose of
diazepam may need to be decreased to avoid excessive sedation.
Dexamethasone may decrease the action of diazepam.
AN: 01587/2022Page 4 of 6
The concomitant use with hepatotoxic dosages of other substances should be
avoided.

This veterinary medicinal product does not require any special storage conditions.

Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.