POM-V Prescription Required Companion Animal

Solu-Medrone V 62.5 mg/ml Powder and Solvent for Solution for Injection

Active ingredient: Methylprednisolone

Form

Injection

Species

Cats Dogs

Manufacturer

Zoetis UK Limited

VMD MA No.

42058/5221

What it's used for

Corticosteroid: For administration to dogs and cats, as a glucocorticoid where a pharmacologically active massive dose is required with a rapid onset of ac...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Methylprednisolone

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Solu-Medrone V 62.5 mg/ml Powder and Solvent for Solution for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Corticosteroid: For administration to dogs and cats, as a glucocorticoid
where a pharmacologically active massive dose is required with a rapid
onset of activity; for example in the treatment of overwhelming
infections/toxicity, shock (as evidenced by collapse of peripheral
circulation with clinical signs of pallor, weak and rapid pulse, shallow
respiration) and spinal cord compression.

Reconstitution: Reconstitute aseptically by adding the contents of the
solvent provided to the freeze-dried powder. Shake well to ensure the
contents are fully dissolved before use. Reconstituted solution should
be used immediately.
Intramuscular or intravenous. Where onset of activity is required within
30-180 minutes the intravenous route should be used; the required
dose should be injected slowly over several minutes given by
intravenous infusion.
For intravenous infusion, the initially prepared solution may be diluted
with 5% dextrose in water, isotonic saline solution or 5% dextrose in
isotonic saline.
When treating overwhelming infections/toxicity or shock, the dose
should be 20 to 30 mg methylprednisolone/kg bodyweight (0.32-0.48
ml/kg); this may be repeated at 4-6 hours for 24-48 hours.
When treating spinal cord compression, the dose should be 30 mg
methylprednisolone/kg bodyweight (0.48 ml /kg) and should be given
within the first two hours of trauma for maximum clinical benefit. The
need for conjunctive surgery or other medicinal treatment should be
considered according to individual clinical status.
Following use at high dosage, there is no need for gradual tailing off,
i.e. therapy can be stopped as soon as clinical examination
demonstrates a stable and improving patient state.

Except in cases of life threatening conditions, use is contra-indicated in
cases where the patient is known or suspected to be suffering from
viral infection, Cushing's Syndrome, congestive heart failure, diabetes
or severe chronic nephritis.

Vomiting may occur as a side effect of rapid intravenous treatment.
Transient polydipsia, polyuria and hyperaesthesia are also possible
side effects. A drop in systemic blood pressure may be produced by a
high dose of methylprednisolone sodium succinate.
Gastrointestinal (g.i.t.) ulceration has been reported in animals treated
with corticosteroids and g.i.t. ulceration may be exacerbated by
steroids in patients given non-steroidal anti-inflammatory drugs and in
corticosteroid treated animals with spinal cord trauma. Steroids may
cause enlargement of the liver (hepatomegaly) with increased serum
hepatic enzymes.
Corticosteroids may delay wound healing and the immunosuppressant
actions may weaken resistance to or exacerbate existing infections. In
the presence of bacterial infection, antibacterial drug cover is usually
required when steroids are used. In the presence of viral infections,
steroids may worsen or hasten the progress of the disease.

Not applicable.

Revised: December 2025
MA split from NI Expiry following AN: 02961/2025

Special precautions for use in animals
Aseptic injection techniques should be practised.
During a course of treatment, the situation should be monitored by
close veterinary supervision.
Special precautions to be taken by the person administering the
veterinary
medicinal product to animals
Care should be taken to avoid accidental self-injection of this potent
drug. In the event of contact with eyes, flush with water or isotonic
saline for 5-10 minutes. In the event of contact with skin, wash with
soap and water.

interaction
Concurrent administration or barbiturates, phenylbutazone, phenytoin
or rifampicin may enhance the metabolism and reduce the effects of
corticosteroids. Response to anti-coagulants may also be reduced by
corticosteroids.

Do not store above 25°C. Do not freeze. Reconstituted solution should
be used immediately.

Revised: December 2025
MA split from NI Expiry following AN: 02961/2025

Not applicable.

Revised: December 2025
MA split from NI Expiry following AN: 02961/2025
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.