POM-V
Prescription Required
Companion Animal
Sedator 1 mg/ml Solution for Injection for Cats and Dogs
Active ingredient: Medetomidine Hydrochloride
Form
Injection
Species
Cats
Dogs
Manufacturer
Eurovet Animal Health B.V.
VMD MA No.
16849/4009
What it's used for
and as a premedicant to thiopentone anaesthesia. Cats: for restraint and sedation. In combination with ketamine for induction of general anaesthesia prior...
Full indications, dosage and side effects ↓The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.
Paying less for Medetomidine Hydrochloride
-
1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
-
2
Fill it at a registered online retailer
The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.
Done — we'll email you when prices land.
Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Clinical information
Sedator 1 mg/ml Solution for Injection for Cats and Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
and as a premedicant to thiopentone anaesthesia.
Cats: for restraint and sedation. In combination with ketamine for induction of general
anaesthesia prior to surgical procedures in the cat. In combination with butorphanol
for sedation and analgesia, and combined with both butorphanol and ketamine for
general anaesthesia. As a premedication before alphaxalone/alphadolone for general
anaesthesia.
AN: 00108/2024 & 00107/2024
Cats: for restraint and sedation. In combination with ketamine for induction of general
anaesthesia prior to surgical procedures in the cat. In combination with butorphanol
for sedation and analgesia, and combined with both butorphanol and ketamine for
general anaesthesia. As a premedication before alphaxalone/alphadolone for general
anaesthesia.
AN: 00108/2024 & 00107/2024
Dosage
Specie
s
DoseEffectVolume
Dogs
10 - 30 μg/kg
30 - 80 μg/kg
10 - 20 μg/kg
Slight sedation
Moderate to deep sedation and analgesia
Pre-anaesthesia
0.1 - 0.3 ml/10 kg
0.3 - 0.8 ml/10 kg
0.1 - 0.2 ml/10 kg
Cats
50 - 100 μg/kg
100 - 150 μg/kg
Moderate sedation
Deep sedation
0.25 - 0.5 ml/5 kg
0.50 - 0.75 ml/5 kg
Maximal effect is obtained within 10-15 minutes. The clinically useful effect is dose-
dependent, lasting 30-180 minutes, but may be repeated if necessary.
Animals should be fasted for 12 hours prior to anaesthesia.
An appropriately graduated syringe must be used to allow accurate administration of
the required dose volume. This is particularly important when injecting small volumes.
AN: 00108/2024 & 00107/2024
Premedication dosing guide: Medetomidinehas marked anaesthetic-sparing effects.
It is essential to reduce appropriately the dose of anaesthetic induction and
maintenance agents in animals that have been given the veterinary medicinal
product.
Dosing guide
MEDETOMIDINE AS A PREMEDICANT BEFORE THIOPENTONE IN DOGS
Anaesthesia is maintained with halothane, with or without nitrous oxide.
Medetomidine is administered at least 20 minutes before thiopentone (inducing
agent) to allow sedation to develop. Guideline doses of thiopentone are as follows:
MedetomidineThiopentoneDose μg/kgVolume of product in ml/10 kgDose of thiopentone in mg/kg100.16.9200.24.5400.42.4
The dose of thiopentone may vary considerably in different animals. The optimum
dose of medetomidine is in the range 20-40 μg/kg and is dependent on the
temperament of the dog. At higher doses of medetomidine, thiopentone may not be
required for intubation.
Thiopentone is administered slowly as a dilute solution, intravenously to effect, over a
period of 30-45 seconds. Once jaw relaxation is adequate, tracheal intubation can be
undertaken. Onset of unconsciousness may be delayed for up to 1 minute following
injection of thiopentone, slow intravenous injection is therefore required as indicated
above. After intubation, anaesthesia may be maintained with halothane in oxygen
(with or without nitrous oxide) administered to effect. Recovery from anaesthesia may
take from 20 to more than 60 minutes. For recoveries in excess of 1 hour it is
advisable to administer atipamezole.
MEDETOMIDINE AS PREMEDICANT BEFORE PROPOFOL IN DOGS
Medetomidine is administered either intravenously at least 10 minutes before
intravenous propofol (induction agent) or intramuscularly at least 20 minutes before
propofol to allow sedation to develop. Medetomidine may be administered at a dose
rate of 10, 20 or 40 micrograms/kg. The following table is a guideline for doses:
MedetomidinePropofol (Induction)Dose in μg/kgVolume of product in ml/10 kgDose of propofol in mg/kg100.11.5200.21.1400.41.0
Following premedication with medetomidine, doses of propofol of up to 4 mg/kg
administered intravenously have been safely used when a greater depth of
anaesthesia is required.
NB. The induction time is increased following premedication, so propofol should be
administered by slow intravenous injection and up to 2.5 minutes should be allowed
before a further dose is given.
Once jaw relaxation is adequate, tracheal intubation can be undertaken. It is
advisable to administer oxygen during anaesthesia.
AN: 00108/2024 & 00107/2024
For maintenance of anaesthesia the dose of propofol is markedly reduced by
medetomidine premedication. Infusion doses of 0.06 to 0.35 mg/kg/minute will
provide stable anaesthesia for dogs sedated with between 40 and 10 μg/kg
medetomidine respectively. For intermittent bolus administration, a dose of 1 mg/kg
of propofol at intervals of between 4 and 12 minutes will provide stable anaesthesia.
Recovery from anaesthesia may take from 20 to > 60 minutes.
Food should be withheld for 12 hours prior to anaesthesia.
Atipamezole administered in the post-operative phase will hasten the recovery from
anaesthesia.
MEDETOMIDINE WITH BUTORPHANOL FOR CANINE SEDATION
Medetomidine and butorphanol can be administered together in the same syringe, by
intramuscular or intravenous injection.
Dose rate: Medetomidine 10-25 μg/kg, depending on the degree of sedation
required, plus 0.1 mg/kg butorphanol. Allow 20 minutes for sedation to develop
before commencing the procedure.
Reversal with an equal volume of Atipamezole to that of the veterinary medicinal
product used results in sternal recumbency approximately 5 minutes later and
standing approximately a further 2 minutes later.
MEDETOMIDINE WITH BUTORPHANOL FOLLOWED BY THIOPENTONE
ANAESTHESIA FOR CANINE SEDATION
Dose rate: Medetomidine 10 μg/kg and butorphanol 0.1 mg/kg
Medetomidine and butorphanol can be administered together in the same syringe, by
intramuscular or intravenous injection.
Allow 20 minutes for sedation to develop before administering thiopentone.
Atipamezole administered in the post-operative phase will hasten recovery from
anaesthesia.
Canine doses (ml) for mild sedation, or premedication prior to thiopentone:
Weight (kg)13510152025303540Sedator 1 mg/ml (dose of
medetomidine 10 μg/kg)
0.010.030.050.100.150.200.250.300.350.40
Butorphanol 10 mg/ml
(dose of butorphanol
0.1 mg/kg)
0.010.030.050.100.150.200.250.300.350.40
Canine doses (ml) for deep sedation:
Weight (kg)13510152025303540Sedator 1 mg/ml (dose of
medetomidine 25 μg/kg)
0.030.080.130.250.380.500.630.750.881.00
Butorphanol 10 mg/ml
(dose of butorphanol
0.1 mg/kg)
0.010.030.050.100.150.200.250.300.350.40
MEDETOMIDINE WITH BUTORPHANOL FOR FELINE SEDATION
Medetomidine and butorphanol can be administered together in the same syringe, by
intramuscular or subcutaneous injection.
Dose rate: Medetomidine 50 μg/kg, depending on the degree of sedation required,
plus 0.40 mg/kg butorphanol. Allow 20 minutes for sedation to develop before
commencing the procedure.
AN: 00108/2024 & 00107/2024
Local anaesthetic infiltration should be used for wound suturing.
Reversal with half volume of Atipamezole 5 mg/ml to that of veterinary medicinal
product used, results in sternal recumbency approximately 4 minutes later and
standing approximately a further 2 minutes later.
Feline doses (ml) for medetomidine/butorphanol sedation:
Weight (kg)11.522.533.544.55Sedator 1 mg/ml (dose of
medetomidine 50 μg/kg)
0.050.080.100.130.150.180.200.230.25
Butorphanol 10 mg/ml
(dose of butorphanol
0.4 mg/kg)
0.040.060.080.100.120.140.160.180.20
MEDETOMIDINE WITH KETAMINE IN CATS
The agents may be given concomitantly, in the same syringe, by the intramuscular
route. To minimise the risk of cross contamination between vials, insert separate
needles into each vial for withdrawal. A dose of 80 μg/kg is recommended for
medetomidine, with 2.5-7.5 mg/kg ketamine giving onset of anaesthesia in 3-4
minutes and a duration of 30-50 minutes for surgical procedures.
Anaesthesia may be prolonged, if required, with halothane and oxygen, with or
without nitrous oxide.
Atropine is not normally necessary when using a medetomidine/ketamine
combination. Food should be withheld for 12 hours prior to anaesthesia.
MEDETOMIDINE, BUTORPHANOL AND KETAMINE FOR FELINE ANAESTHESIA
a) Intramuscular
Dosage: Medetomidine 80 μg/kg, butorphanol 0.4 mg/kg and ketamine 5 mg/kg can
be given in a single syringe.
Cats become recumbent in 2-3 minutes following injection. Loss of pedal reflex
occurs 3 minutes post injection.
Reversal by 200 μg/kg atipamezole results in return of pedal reflex 2 minutes later,
sternal recumbency 6 minutes later and standing 31 minutes later.
Feline doses (ml) for intramuscular medetomidine/butorphanol/ketamine anaesthesia:
Weight (kg)11.522.533.544.55Sedator 1 mg/ml (dose
of medetomidine 80
μg/kg)
0.080.120.160.200.240.280.320.360.40
Butorphanol 10 mg/ml
(dose of butorphanol
0.4 mg/kg)
0.040.060.080.100.120.140.160.180.20
Ketamine 100 mg/ml
(dose of ketamine 5
mg/kg)
0.050.0750.100.1250.150.1750.200.2250.25
b) Intravenous
Dosage: Medetomidine 40 μg/kg, butorphanol 0.1 mg/kg and ketamine from 1.25 to
2.5 mg/kg (depending on depth of anaesthesia required).
Reversal by 100 μg/kg of atipamezole results in return of pedal reflex 4 minutes later,
sternal recumbency 7 minutes later and standing 18 minutes later.
AN: 00108/2024 & 00107/2024
Feline doses (ml) for intravenous medetomidine/butorphanol/ketamine anaesthesia:
Weight (kg)11.522.533.544.55Sedator 1 mg/ml (dose of
medetomidine 40 μg/kg)
0.040.060.080.100.120.140.160.180.20
Butorphanol 10 mg/ ml
(dose of butorphanol
0.1 mg/kg)
0.010.020.020.030.030.040.040.050.05
EITHER Ketamine 100
mg/ml (dose of ketamine
1.25 mg/kg)
0.010.020.030.030.040.040.050.060.06
OR Ketamine 100 mg/ml
(dose of ketamine
2.5 mg/kg)
0.030.040.050.060.080.090.100.110.13
Approximate time scales in intravenous medetomidine/butorphanol/ketamine
anaesthesia:
Ketamine
dose
Time to
recumbency
Time to
loss of
pedal
reflex
Time to
return of
pedal
reflex
Time to
sternal
recumbenc
y
Time to
standing
1.25 mg/kg32 secs62 secs26 mins54 mins74 mins2.5 mg/kg22 secs39 secs28 mins62 mins83 mins
MEDETOMIDINE FOLLOWED BY ALPHAXALONE/ALPHADOLONE FOR
GENERAL ANAESTHESIA
Dosage: Administer medetomidine 80 μg/kg by intramuscular or subcutaneous
injection. 15-60 minutes later administer 2.5-5.0 mg/kg alphaxalone/alphadolone
intravenously. Anaesthesia may be maintained by further intravenous injections of
alphaxalone/alphadolone, or by administration of halothane in oxygen.
Feline doses (ml) for medetomidine/alphaxalone/alphadolone anaesthesia:
Weight (kg)11.522.533.544.55Sedator 1 mg/ml
(medetomidine)
80 μg/kg0.080.120.160.200.240.280.320.360.40
Alphaxalone 9
mg/ml
/Alphadolone 3
mg/ml
minimum
dose
=
2.5 mg/kg
0.210.310.420.520.630.730.830.941.04
Alphaxalone 9
mg/ml
/Alphadolone 3
mg/ml
maximum
dose =
5 mg/kg
0.420.630.831.041.251.461.671.882.08
Specie
s
DoseEffectVolume
Dogs
10 - 30 μg/kg
30 - 80 μg/kg
10 - 20 μg/kg
Slight sedation
Moderate to deep sedation and analgesia
Pre-anaesthesia
0.1 - 0.3 ml/10 kg
0.3 - 0.8 ml/10 kg
0.1 - 0.2 ml/10 kg
Cats
50 - 100 μg/kg
100 - 150 μg/kg
Moderate sedation
Deep sedation
0.25 - 0.5 ml/5 kg
0.50 - 0.75 ml/5 kg
Maximal effect is obtained within 10-15 minutes. The clinically useful effect is dose-
dependent, lasting 30-180 minutes, but may be repeated if necessary.
Animals should be fasted for 12 hours prior to anaesthesia.
An appropriately graduated syringe must be used to allow accurate administration of
the required dose volume. This is particularly important when injecting small volumes.
AN: 00108/2024 & 00107/2024
Premedication dosing guide: Medetomidinehas marked anaesthetic-sparing effects.
It is essential to reduce appropriately the dose of anaesthetic induction and
maintenance agents in animals that have been given the veterinary medicinal
product.
Dosing guide
MEDETOMIDINE AS A PREMEDICANT BEFORE THIOPENTONE IN DOGS
Anaesthesia is maintained with halothane, with or without nitrous oxide.
Medetomidine is administered at least 20 minutes before thiopentone (inducing
agent) to allow sedation to develop. Guideline doses of thiopentone are as follows:
MedetomidineThiopentoneDose μg/kgVolume of product in ml/10 kgDose of thiopentone in mg/kg100.16.9200.24.5400.42.4
The dose of thiopentone may vary considerably in different animals. The optimum
dose of medetomidine is in the range 20-40 μg/kg and is dependent on the
temperament of the dog. At higher doses of medetomidine, thiopentone may not be
required for intubation.
Thiopentone is administered slowly as a dilute solution, intravenously to effect, over a
period of 30-45 seconds. Once jaw relaxation is adequate, tracheal intubation can be
undertaken. Onset of unconsciousness may be delayed for up to 1 minute following
injection of thiopentone, slow intravenous injection is therefore required as indicated
above. After intubation, anaesthesia may be maintained with halothane in oxygen
(with or without nitrous oxide) administered to effect. Recovery from anaesthesia may
take from 20 to more than 60 minutes. For recoveries in excess of 1 hour it is
advisable to administer atipamezole.
MEDETOMIDINE AS PREMEDICANT BEFORE PROPOFOL IN DOGS
Medetomidine is administered either intravenously at least 10 minutes before
intravenous propofol (induction agent) or intramuscularly at least 20 minutes before
propofol to allow sedation to develop. Medetomidine may be administered at a dose
rate of 10, 20 or 40 micrograms/kg. The following table is a guideline for doses:
MedetomidinePropofol (Induction)Dose in μg/kgVolume of product in ml/10 kgDose of propofol in mg/kg100.11.5200.21.1400.41.0
Following premedication with medetomidine, doses of propofol of up to 4 mg/kg
administered intravenously have been safely used when a greater depth of
anaesthesia is required.
NB. The induction time is increased following premedication, so propofol should be
administered by slow intravenous injection and up to 2.5 minutes should be allowed
before a further dose is given.
Once jaw relaxation is adequate, tracheal intubation can be undertaken. It is
advisable to administer oxygen during anaesthesia.
AN: 00108/2024 & 00107/2024
For maintenance of anaesthesia the dose of propofol is markedly reduced by
medetomidine premedication. Infusion doses of 0.06 to 0.35 mg/kg/minute will
provide stable anaesthesia for dogs sedated with between 40 and 10 μg/kg
medetomidine respectively. For intermittent bolus administration, a dose of 1 mg/kg
of propofol at intervals of between 4 and 12 minutes will provide stable anaesthesia.
Recovery from anaesthesia may take from 20 to > 60 minutes.
Food should be withheld for 12 hours prior to anaesthesia.
Atipamezole administered in the post-operative phase will hasten the recovery from
anaesthesia.
MEDETOMIDINE WITH BUTORPHANOL FOR CANINE SEDATION
Medetomidine and butorphanol can be administered together in the same syringe, by
intramuscular or intravenous injection.
Dose rate: Medetomidine 10-25 μg/kg, depending on the degree of sedation
required, plus 0.1 mg/kg butorphanol. Allow 20 minutes for sedation to develop
before commencing the procedure.
Reversal with an equal volume of Atipamezole to that of the veterinary medicinal
product used results in sternal recumbency approximately 5 minutes later and
standing approximately a further 2 minutes later.
MEDETOMIDINE WITH BUTORPHANOL FOLLOWED BY THIOPENTONE
ANAESTHESIA FOR CANINE SEDATION
Dose rate: Medetomidine 10 μg/kg and butorphanol 0.1 mg/kg
Medetomidine and butorphanol can be administered together in the same syringe, by
intramuscular or intravenous injection.
Allow 20 minutes for sedation to develop before administering thiopentone.
Atipamezole administered in the post-operative phase will hasten recovery from
anaesthesia.
Canine doses (ml) for mild sedation, or premedication prior to thiopentone:
Weight (kg)13510152025303540Sedator 1 mg/ml (dose of
medetomidine 10 μg/kg)
0.010.030.050.100.150.200.250.300.350.40
Butorphanol 10 mg/ml
(dose of butorphanol
0.1 mg/kg)
0.010.030.050.100.150.200.250.300.350.40
Canine doses (ml) for deep sedation:
Weight (kg)13510152025303540Sedator 1 mg/ml (dose of
medetomidine 25 μg/kg)
0.030.080.130.250.380.500.630.750.881.00
Butorphanol 10 mg/ml
(dose of butorphanol
0.1 mg/kg)
0.010.030.050.100.150.200.250.300.350.40
MEDETOMIDINE WITH BUTORPHANOL FOR FELINE SEDATION
Medetomidine and butorphanol can be administered together in the same syringe, by
intramuscular or subcutaneous injection.
Dose rate: Medetomidine 50 μg/kg, depending on the degree of sedation required,
plus 0.40 mg/kg butorphanol. Allow 20 minutes for sedation to develop before
commencing the procedure.
AN: 00108/2024 & 00107/2024
Local anaesthetic infiltration should be used for wound suturing.
Reversal with half volume of Atipamezole 5 mg/ml to that of veterinary medicinal
product used, results in sternal recumbency approximately 4 minutes later and
standing approximately a further 2 minutes later.
Feline doses (ml) for medetomidine/butorphanol sedation:
Weight (kg)11.522.533.544.55Sedator 1 mg/ml (dose of
medetomidine 50 μg/kg)
0.050.080.100.130.150.180.200.230.25
Butorphanol 10 mg/ml
(dose of butorphanol
0.4 mg/kg)
0.040.060.080.100.120.140.160.180.20
MEDETOMIDINE WITH KETAMINE IN CATS
The agents may be given concomitantly, in the same syringe, by the intramuscular
route. To minimise the risk of cross contamination between vials, insert separate
needles into each vial for withdrawal. A dose of 80 μg/kg is recommended for
medetomidine, with 2.5-7.5 mg/kg ketamine giving onset of anaesthesia in 3-4
minutes and a duration of 30-50 minutes for surgical procedures.
Anaesthesia may be prolonged, if required, with halothane and oxygen, with or
without nitrous oxide.
Atropine is not normally necessary when using a medetomidine/ketamine
combination. Food should be withheld for 12 hours prior to anaesthesia.
MEDETOMIDINE, BUTORPHANOL AND KETAMINE FOR FELINE ANAESTHESIA
a) Intramuscular
Dosage: Medetomidine 80 μg/kg, butorphanol 0.4 mg/kg and ketamine 5 mg/kg can
be given in a single syringe.
Cats become recumbent in 2-3 minutes following injection. Loss of pedal reflex
occurs 3 minutes post injection.
Reversal by 200 μg/kg atipamezole results in return of pedal reflex 2 minutes later,
sternal recumbency 6 minutes later and standing 31 minutes later.
Feline doses (ml) for intramuscular medetomidine/butorphanol/ketamine anaesthesia:
Weight (kg)11.522.533.544.55Sedator 1 mg/ml (dose
of medetomidine 80
μg/kg)
0.080.120.160.200.240.280.320.360.40
Butorphanol 10 mg/ml
(dose of butorphanol
0.4 mg/kg)
0.040.060.080.100.120.140.160.180.20
Ketamine 100 mg/ml
(dose of ketamine 5
mg/kg)
0.050.0750.100.1250.150.1750.200.2250.25
b) Intravenous
Dosage: Medetomidine 40 μg/kg, butorphanol 0.1 mg/kg and ketamine from 1.25 to
2.5 mg/kg (depending on depth of anaesthesia required).
Reversal by 100 μg/kg of atipamezole results in return of pedal reflex 4 minutes later,
sternal recumbency 7 minutes later and standing 18 minutes later.
AN: 00108/2024 & 00107/2024
Feline doses (ml) for intravenous medetomidine/butorphanol/ketamine anaesthesia:
Weight (kg)11.522.533.544.55Sedator 1 mg/ml (dose of
medetomidine 40 μg/kg)
0.040.060.080.100.120.140.160.180.20
Butorphanol 10 mg/ ml
(dose of butorphanol
0.1 mg/kg)
0.010.020.020.030.030.040.040.050.05
EITHER Ketamine 100
mg/ml (dose of ketamine
1.25 mg/kg)
0.010.020.030.030.040.040.050.060.06
OR Ketamine 100 mg/ml
(dose of ketamine
2.5 mg/kg)
0.030.040.050.060.080.090.100.110.13
Approximate time scales in intravenous medetomidine/butorphanol/ketamine
anaesthesia:
Ketamine
dose
Time to
recumbency
Time to
loss of
pedal
reflex
Time to
return of
pedal
reflex
Time to
sternal
recumbenc
y
Time to
standing
1.25 mg/kg32 secs62 secs26 mins54 mins74 mins2.5 mg/kg22 secs39 secs28 mins62 mins83 mins
MEDETOMIDINE FOLLOWED BY ALPHAXALONE/ALPHADOLONE FOR
GENERAL ANAESTHESIA
Dosage: Administer medetomidine 80 μg/kg by intramuscular or subcutaneous
injection. 15-60 minutes later administer 2.5-5.0 mg/kg alphaxalone/alphadolone
intravenously. Anaesthesia may be maintained by further intravenous injections of
alphaxalone/alphadolone, or by administration of halothane in oxygen.
Feline doses (ml) for medetomidine/alphaxalone/alphadolone anaesthesia:
Weight (kg)11.522.533.544.55Sedator 1 mg/ml
(medetomidine)
80 μg/kg0.080.120.160.200.240.280.320.360.40
Alphaxalone 9
mg/ml
/Alphadolone 3
mg/ml
minimum
dose
=
2.5 mg/kg
0.210.310.420.520.630.730.830.941.04
Alphaxalone 9
mg/ml
/Alphadolone 3
mg/ml
maximum
dose =
5 mg/kg
0.420.630.831.041.251.461.671.882.08
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients. Do not use in conjunction with sympathomimetic amines. Care should be
taken with the use of medetomidine in animals with cardiovascular disease or in poor
general health.
Before using any combinations consult the contraindications and warnings that
appear on the other veterinary medicinal products’ data sheet.
Medetomidine should not be used with thiopentone or propofol in animals with
cardiac or respiratory disease (see also section 3.10).
excipients. Do not use in conjunction with sympathomimetic amines. Care should be
taken with the use of medetomidine in animals with cardiovascular disease or in poor
general health.
Before using any combinations consult the contraindications and warnings that
appear on the other veterinary medicinal products’ data sheet.
Medetomidine should not be used with thiopentone or propofol in animals with
cardiac or respiratory disease (see also section 3.10).
Dogs and cats:
Very rare
(1 animal / 10,000 animals
treated, including isolated
reports):
Bradycardia, Hypertension
a
, Hypotension
a
Decreased respiratory rate
b
Hypothermia
c
Vomiting
d
Polyuria
e
AN: 00108/2024 & 00107/2024
a
Blood pressure will increase initially and then return to normal or slightly below.
b
In some dogs and cats (see also section 3.10).
c
Treated animals should be kept in a warm and even temperature during the
procedures and for 12 hours after sedation.
d
Some dogs and most cats vomit 5-10 minutes after injection. Some cats may also
vomit on recovery.
e
May be associated with recovery.
By virtue of this α2-adrenergic
conductivity.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Very rare
(1 animal / 10,000 animals
treated, including isolated
reports):
Bradycardia, Hypertension
a
, Hypotension
a
Decreased respiratory rate
b
Hypothermia
c
Vomiting
d
Polyuria
e
AN: 00108/2024 & 00107/2024
a
Blood pressure will increase initially and then return to normal or slightly below.
b
In some dogs and cats (see also section 3.10).
c
Treated animals should be kept in a warm and even temperature during the
procedures and for 12 hours after sedation.
d
Some dogs and most cats vomit 5-10 minutes after injection. Some cats may also
vomit on recovery.
e
May be associated with recovery.
By virtue of this α2-adrenergic
conductivity.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
An appropriately graduated syringe must be used to allow accurate administration of
the required dose volume. This is particularly important when injecting small volumes
MEDETOMIDINE WITH KETAMINE IN CATS
Medetomidine and ketamine are metabolised in the liver and excreted mainly via the
kidneys, therefore any pre-existing hepatic or renal pathology must be carefully
evaluated before considering this method of anaesthesia. Vomiting prior to onset of
anaesthesia occurs in approximately 10% of cases. Laryngeal and pharyngeal
reflexes are retained during anaesthesia. The combination is reported to elicit a pain
response in some cats when administered intramuscularly. Heart rates will generally
fall to approximately 50% of pre-anaesthetic levels and in some cats very slow
respiratory rates are observed (4-6 breaths per minute). Where procedures are
prolonged, it may be helpful to apply an eye preparation at regular intervals to
lubricate the cornea. During and after anaesthesia, treated animals should be kept in
a warm and even temperature.
Medetomidine must not be mixed with other ketamine products, with the exception of
Vetalar.
MEDETOMIDINE AS A PREMEDICANT BEFORE THIOPENTONE IN DOGS
Anaesthesia being maintained with halothane (with or without nitrous oxide). This
regime should not be used in animals with cardiovascular or respiratory disease.
Medetomidine and thiopentone are metabolised in the liver and excreted via the
kidneys; any pre-existing hepatic or renal pathology must be carefully evaluated
before considering this method of anaesthesia.
Medetomidine has marked anaesthetic sparing effects. Therefore, it should be
ensured that the dose of thiopentone and halothane is reduced accordingly and is
administered with care to minimise the possibility of inadvertent overdosage.
Respiratory rates may fall by up to 30% of pre-dose values following administration of
medetomidine. Heart rates will fall following the administration of medetomidine and
they will not return to presedation levels following induction. Occasionally there will
be a transient rise in heart rate associated with induction followed by bradycardia.
During and after anaesthesia, treated animals should be kept in warm and even
temperature.
MEDETOMIDINE AS A PREMEDICANT BEFORE PROPOFOL IN DOGS
This regime should not be used in animals with cardiovascular or respiratory disease.
Medetomidine and propofol are metabolised in the liver and excreted via the kidneys;
any pre-existing hepatic or renal pathology must be carefully evaluated before
considering this method of anaesthesia. Medetomidine has marked anaesthetic
sparing effects, therefore it should be ensured that the dose of propofol is reduced
AN: 00108/2024 & 00107/2024
accordingly and is administered with care to minimise the possibility of inadvertent
overdosage.
Transient apnoea and movement of the forelegs may occur during induction of
anaesthesia and in some cases at higher dosages, a decline in arterial oxygen
tension may occur. When using this regime dogs should be intubated and oxygen
administered during anaesthesia.
During and after anaesthesia, treated animals should be kept in a warm and even
temperature.
Special precautions for safe use in the target species:
Care should be taken with the use of medetomidine in animals with cardiovascular
disease or in poor general health.
Medetomidine, ketamine and thiopentone are metabolised in the liver and excreted
mainly via the kidneys. Pre-existing liver or kidney pathology should be carefully
evaluated prior to using these veterinary medicinal products (see also section 3.7 and
3.10).
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
To the user:
In case of accidental self-injection or ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician, but DO NOT DRIVE as
sedation and changes in blood pressure may occur.
Avoid skin, eye or mucosal contact.
Immediately after exposure, wash the exposed skin with large amounts of fresh
water.
In case of accidental eye contact, rinse with large amounts of fresh water. If
symptoms occur, seek the advice of a doctor.
If pregnant women handle the veterinary medicinal product, special caution should be
observed not to self-inject as uterine contractions and decreased foetal blood
pressure may occur after accidental systemic exposure.
To the physician:
Medetomidine is an alpha2-adrenoreceptor agonist. Symptoms after absorption may
involve clinical effects including dose-dependent sedation, respiratory depression,
bradycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular arrhythmias
have also been reported. Respiratory and haemodynamic symptoms should be
treated symptomatically.
Special precautions for the protection of the environment:
Not applicable.
the required dose volume. This is particularly important when injecting small volumes
MEDETOMIDINE WITH KETAMINE IN CATS
Medetomidine and ketamine are metabolised in the liver and excreted mainly via the
kidneys, therefore any pre-existing hepatic or renal pathology must be carefully
evaluated before considering this method of anaesthesia. Vomiting prior to onset of
anaesthesia occurs in approximately 10% of cases. Laryngeal and pharyngeal
reflexes are retained during anaesthesia. The combination is reported to elicit a pain
response in some cats when administered intramuscularly. Heart rates will generally
fall to approximately 50% of pre-anaesthetic levels and in some cats very slow
respiratory rates are observed (4-6 breaths per minute). Where procedures are
prolonged, it may be helpful to apply an eye preparation at regular intervals to
lubricate the cornea. During and after anaesthesia, treated animals should be kept in
a warm and even temperature.
Medetomidine must not be mixed with other ketamine products, with the exception of
Vetalar.
MEDETOMIDINE AS A PREMEDICANT BEFORE THIOPENTONE IN DOGS
Anaesthesia being maintained with halothane (with or without nitrous oxide). This
regime should not be used in animals with cardiovascular or respiratory disease.
Medetomidine and thiopentone are metabolised in the liver and excreted via the
kidneys; any pre-existing hepatic or renal pathology must be carefully evaluated
before considering this method of anaesthesia.
Medetomidine has marked anaesthetic sparing effects. Therefore, it should be
ensured that the dose of thiopentone and halothane is reduced accordingly and is
administered with care to minimise the possibility of inadvertent overdosage.
Respiratory rates may fall by up to 30% of pre-dose values following administration of
medetomidine. Heart rates will fall following the administration of medetomidine and
they will not return to presedation levels following induction. Occasionally there will
be a transient rise in heart rate associated with induction followed by bradycardia.
During and after anaesthesia, treated animals should be kept in warm and even
temperature.
MEDETOMIDINE AS A PREMEDICANT BEFORE PROPOFOL IN DOGS
This regime should not be used in animals with cardiovascular or respiratory disease.
Medetomidine and propofol are metabolised in the liver and excreted via the kidneys;
any pre-existing hepatic or renal pathology must be carefully evaluated before
considering this method of anaesthesia. Medetomidine has marked anaesthetic
sparing effects, therefore it should be ensured that the dose of propofol is reduced
AN: 00108/2024 & 00107/2024
accordingly and is administered with care to minimise the possibility of inadvertent
overdosage.
Transient apnoea and movement of the forelegs may occur during induction of
anaesthesia and in some cases at higher dosages, a decline in arterial oxygen
tension may occur. When using this regime dogs should be intubated and oxygen
administered during anaesthesia.
During and after anaesthesia, treated animals should be kept in a warm and even
temperature.
Special precautions for safe use in the target species:
Care should be taken with the use of medetomidine in animals with cardiovascular
disease or in poor general health.
Medetomidine, ketamine and thiopentone are metabolised in the liver and excreted
mainly via the kidneys. Pre-existing liver or kidney pathology should be carefully
evaluated prior to using these veterinary medicinal products (see also section 3.7 and
3.10).
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
To the user:
In case of accidental self-injection or ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician, but DO NOT DRIVE as
sedation and changes in blood pressure may occur.
Avoid skin, eye or mucosal contact.
Immediately after exposure, wash the exposed skin with large amounts of fresh
water.
In case of accidental eye contact, rinse with large amounts of fresh water. If
symptoms occur, seek the advice of a doctor.
If pregnant women handle the veterinary medicinal product, special caution should be
observed not to self-inject as uterine contractions and decreased foetal blood
pressure may occur after accidental systemic exposure.
To the physician:
Medetomidine is an alpha2-adrenoreceptor agonist. Symptoms after absorption may
involve clinical effects including dose-dependent sedation, respiratory depression,
bradycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular arrhythmias
have also been reported. Respiratory and haemodynamic symptoms should be
treated symptomatically.
Special precautions for the protection of the environment:
Not applicable.
Medetomidine should not be used in conjunction with sympathomimetic amines. The
concomitant use of other central nervous system depressants should be expected to
potentiate the effect of either veterinary medicinal product and appropriate dose
adjustment should be made.
Medetomidine has marked anaesthetic sparing effects. The dose of compounds such
as thiopentone, halothane and propofol should be reduced accordingly.
concomitant use of other central nervous system depressants should be expected to
potentiate the effect of either veterinary medicinal product and appropriate dose
adjustment should be made.
Medetomidine has marked anaesthetic sparing effects. The dose of compounds such
as thiopentone, halothane and propofol should be reduced accordingly.
Keep the vial in the outer carton. This veterinary medicinal product does not require
any special temperature storage conditions.
any special temperature storage conditions.
Not applicable.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
Medication costs adding up?
Pet insurance can cover prescription medications. Find the right policy for your pet.
Same active ingredient
Other Products Containing Medetomidine Hydrochloride
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Domitor 1 mg/ml Solution for Injection
POM-VOrion Corporation
injection
Cats
Dogs
Dorbene Vet 1 mg/ml Solution for Injection for Dogs and Cats
POM-VLaboratorios SYVA S.A.
injection
Cats
Dogs
Dormostart 1 mg/ml Solution for Injection for Dogs and Cats
POM-VAlfasan Nederland B.V.
injection
Cats
Dogs
Dormostart 1 mg/ml Solution for Injection for Dogs and Cats
POM-VAlfasan Nederland B.V.
injection
Cats
Dogs
Medetocord 1 mg/ml Solution for Injection for Dogs and Cats
POM-VVetpharma Animal Health, S.L
injection
Cats
Dogs
Medetor 1 mg/ml Solution for Injection for Dog and Cat
POM-VCP Pharma Handelsgesellschaft mbH
injection
Cats
Dogs
Alternative options to consider
Retailers we earn a commission from. It costs you nothing and never changes what we show.
The Pharm Pet Co.
The Pharm Pet Co. — Pet Pharmacy
UK online pet pharmacy. Flea, worm, prescription medications, supplements and pet food. Save vs vet prices.
Save up to 50%
Shop now
Pharmacy2U
Pet Care at Pharmacy2U
The UK's largest online pharmacy. Pet wormers, flea treatments, dental and joint care. Free delivery on orders over £30.
Free delivery £30+
Shop now
Petlibro
Petlibro Automatic Feeder
Smart automatic pet feeder with app control. Schedule meals, portion control, and feeding history.
From £49.99
Shop now
We may earn a small commission if you purchase through these links, at no extra cost to you.
Also in sedative
Related Medications
Acecare 2mg/ml Solution for Injection for Dogs and Cats
POM-VAcepromazine
injection
Rx
Cats
Dogs
AceSedate 10 mg/ml Solution for Injection for Horses
POM-VAcepromazine
injection
Rx
Horses
AceSedate 2 mg/ml Solution for Injection for Dogs and Cats
POM-VAcepromazine
injection
Rx
Cats
Dogs
ACP Injection 2 mg/ml Solution for Injection
POM-VAcepromazine
injection
Rx
Cats
Dogs
ACP Injection 2 mg/ml Solution for Injection
POM-VAcepromazine
injection
Rx
Cats
Dogs
Azaporc 40 mg/ml Solution for Injection for Pigs
POM-VAzaperone
injection
Rx
Pigs
Find cheaper vets near you
Compare vet consultation prices in your area. Save on procedures and get a prescription to buy medications online.