Prilactone Next 100 mg Chewable Tablets for Dogs
Active ingredient: Spironolactone
Form
Chewable
Species
Manufacturer
Ceva Sante Animale
VMD MA No.
14966/5090
What it's used for
For use in combination with standard therapy (including diuretic support, where necessary) for the treatment of congestive heart failure caused by degenera...
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Paying less for Spironolactone
-
1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
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2
Fill it at a registered online retailer
The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Prilactone Next 100 mg Chewable Tablets for Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
necessary) for the treatment of congestive heart failure caused by degenerative
mitral valve disease in dogs.
Do not use in dogs suffering from hypoadrenocorticism, hyperkalaemia or
hyponatraemia.
Do not administer spironolactone in conjunction with NSAIDs to dogs with renal
insufficiency.
Do not use in cases of hypersensitivity to spironolactone or any of the excipients.
See section 4.7.
Very common
(>1 animal / 10 animals
treated):
Prostatic atrophy
Common
(1 to 10 animals / 100 animals
treated):
Vomiting, Diarrhoea
in entire male dogs, reversible
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or the national competent authority via
the national reporting system. See the package leaflet for respective contact details.
Revised: November 2025
AN: 02289/2025
Special precautions for use in animals
Kidney function and plasma potassium levels should be evaluated before initiating
combined treatment with spironolactone and ACE inhibitors. Unlike in humans, an
increased incidence of hyperkalaemia was not observed in clinical trials performed
in dogs with this combination. However, in dogs with renal impairment, regular
monitoring of renal function and plasma potassium levels is recommended as there
may be an increased risk of hyperkalaemia.
Dogs treated concomitantly with spironolactone and NSAIDs should be correctly
hydrated. Monitoring of their renal function and plasma potassium levels is
recommended before initiation and during treatment with combined therapy (see
4.3). As spironolactone has an antiandrogenic effect, it is not recommended to
administer the product to growing dogs.
As spironolactone undergoes extensive hepatic biotransformation, care should be
taken when using the product to treat dogs with hepatic dysfunction.
The chewable tablets are flavoured. In order to avoid accidental ingestion, store
these tablets out of the reach of animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
The product may cause skin sensitization. Persons known to be allergic to
spironolactone or other components of the final formulation should not handle this
product.
Handle this product with great care to avoid unnecessary exposure, taking all
recommended precautions.
Wash hands after use.
If you develop symptoms following exposure such as a skin rash, you should seek
medical advice and show the doctor this warning. Swelling of the face, lips or eyes
or difficulty with breathing are more serious symptoms and require urgent medical
attention.
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment
Not applicable
Other precautions
Not applicable
Revised: November 2025
AN: 02289/2025
and pimobendan without evidence of associated adverse reactions.
Spironolactone decreases digoxin elimination and hence raises digoxin plasma
concentration. As the therapeutic index for digoxin is very narrow, it is advisable to
monitor closely dogs receiving both digoxin and spironolactone.
The administration of either deoxycorticosterone or NSAIDs with spironolactone
may lead to a moderate reduction of the natriuretic effects (reduction of urinary
sodium excretion) of spironolactone.
Concomitant administration of spironolactone with ACE-inhibitors and other
potassium-sparing drugs (as angiotensin receptor blockers, ß-blockers, calcium
channels blockers, etc..) may potentially lead to hyperkalaemia (see 4.5).
Spironolactone may cause both induction and inhibition of cytochrome P450
enzymes and could therefore affect the metabolism of other drugs utilizing these
metabolic pathways.
Store in the original package.
Any part-used tablet should be returned to the opened blister and used within 72
hours.
then the tablets may be mixed with a small amount of food offered prior to the main
meal, or administered directly into the mouth after feeding.
Instruction on how to divide the tablet: Put the tablet on an even surface, with its
scored side facing down (convex face up). With the tip of the forefinger, exert slight
vertical pressure on the middle of the tablet to break it along its width into halves.
Then, in order to obtain quarters, exert slight pressure on the middle of one half
with the forefinger to break it into two parts.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
After administration of up to 5 times the recommended dose (10 mg/kg) to healthy
dogs, dose-dependent adverse effects were noted, see section 4.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Spironolactone
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