POM-V Prescription Required

Presedine 10 mg/ml Solution for Injection for Horses

Active ingredient: Detomidine Hydrochloride

Form

Injection

Species

Horses

Manufacturer

Alfasan Nederland B.V.

VMD MA No.

36408/5019

What it's used for

A sedative with analgesic properties used to facilitate handling of horses for examination, minor surgical interventions and other manipulations. It can be...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Detomidine Hydrochloride

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Presedine 10 mg/ml Solution for Injection for Horses — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

A sedative with analgesic properties used to facilitate handling of horses for
examination, minor surgical interventions and other manipulations. It can be
used with or without butorphanol.
The product is also indicated for use with ketamine for short duration general
anaesthesia to carry out surgical procedures such as castration.

Do not use in conjunction with sympathomimetic amines or with
intravenous potentiated sulphonamides.
Do not administer simultaneously with ketamine in the same syringe (see
sections 4.8 and 4.9).

Issued: August 2023
AN: 00718/2022
Do not use the butorphanol combination in horses suffering from colic. Do not
use in seriously ill animals with heart failure or impaired liver or kidney function.
Do not use in case of hypersensitivity to the active substance or to any of the
excipients.
Do not administer to horses in the last month of pregnancy.

Adverse reactions are very rare. All alpha-2 adrenoceptor agonists, including
detomidine, may cause decreased heart rate, changes in the conductivity of
cardiac muscle (as evidenced by partial atrioventricular and sinoatrial blocks),
changes in the respiratory rate, incoordination/ataxia and sweating.
A diuretic effect is usually observed within 45 to 60 minutes after treatment.
The potential for isolated cases of hypersensitivity exists, including paradoxical
response (excitation).
Partial, transient penis prolapse may occur in male horses.
In rare cases, horses may show signs of mild colic following administration of
alpha-2 adrenoceptor agonists because substances of this class inhibit
intestinal motility.
Occasional reports of urticaria have been received. Mild adverse reactions
have reportedly resolved without treatment. Severe reactions should be treated
symptomatically.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reaction(s)
during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals )
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports)

Issued: August 2023
AN: 00718/2022

None

i) Special precautions for use in animals
The product should not be used in horses with pre-existing AV blocks,
with severe cardiac insufficiency, respiratory disease or chronic renal
failure.
Careful consideration should be given prior to administration to animals
in shock and to animals with liver or kidney disease.
Intravenous administration should be slow.
It is recommended that feed should be withheld for at least 12 hours
prior to anaesthesia.
The horse should not be given water or feed before the drug effect has
passed.
Routine safety measures should be employed to protect practitioners
and handlers
ii) Special precautions to be taken by the person administering the
veterinary medicinal product to animals
In the case of accidental oral intake or self-injection, seek medical advice
immediately and show the package leaflet to the doctor but DO NOT
DRIVE as sedation and changes in blood pressure may occur.
Avoid skin, eye or mucosal contact.
Immediately after exposure, wash the exposed skin with large amounts
of fresh water.
Remove contaminated clothes that are in direct contact with skin.

Issued: August 2023
AN: 00718/2022
In the case of accidental contact of the product with eyes, rinse with
large amounts of fresh water. If symptoms occur, seek the advice of a
doctor.
If pregnant women handle the product, special caution should be
observed not to self inject as uterine contractions and decreased foetal
blood pressure may occur after accidental systemic exposure.
Advice to the Doctor:
Detomidine hydrochloride is an alpha-2 adrenoreceptor agonist.
Symptoms after absorption may involve clinical effects including dose-
dependent sedation, respiratory depression, bradycardia, hypotension,
a dry mouth, and hyperglycaemia. Ventricular arrhythmias have also
been reported. Respiratory and haemodynamic symptoms should be
treated symptomatically.
iii) Other precautions
Not applicable.

Use with care with other sedatives and anaesthetics because of an
additive/synergistic effect.
Where appropriate the product may be used in conjunction with local
anaesthetic agents.
Induction of anaesthesia with detomidine and ketamine has been used prior to
maintenance with halothane. Because of the nature of the induction gents, the
effects of halothane may be delayed and special care must be taken to avoid
over-dosage.
When detomidine is used as a premedication prior to general anaesthesia, the
product may delay onset of induction.
Use in conjunction with sympathomimetic amines and intravenous potentiated
sulphonamides is contra-indicated.

This veterinary medicinal product does not require any special storage
conditions.

Issued: August 2023
AN: 00718/2022

Meat and offal: 1 Day
Milk: 12 hours
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.