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POM-V Prescription Required Companion Animal

Prazemo Spot-On Worming Solution 60 mg/15 mg Spot-on Solution for Medium Cats

Active ingredients: Emodepside, Praziquantel

Form

Spot-on

Species

Cats

Manufacturer

KRKA, d.d., Novo mesto

VMD MA No.

01656/5108

What it's used for

For dogs, when mixed parasitic infections caused by roundworms and coccidia of the following species are suspected or demonstrated: Roundworms (Nematodes):...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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  1. 1

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Prazemo Spot-On Worming Solution 60 mg/15 mg Spot-on Solution for Medium Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For dogs, when mixed parasitic infections caused by roundworms and coccidia of the
following species are suspected or demonstrated:
Roundworms (Nematodes):
- (mature adult, immature adult, L4)
-
-
- (mature adult)
Coccidia:
-complex
-

Revised: November 2023
AN: 01821/2023
Procox is effective against the replication of Isospora and also against the shedding
of oocysts. Although treatment will reduce the spread of infection, it will not be
effective against the clinical signs of infection in already infected animals.
Dosage and Treatment Schedule
The recommended minimum doses are 12 mg praziquantel / kg body weight and 3
mg emodepside / kg body weight, equivalent to 0.14 ml of the veterinary medicinal
product / kg body weight.
Body weight
of the cat
(kg)
Pipette size/volume
(ml) to be used
Praziquantel (mg/kg
body weight)
Emodepside (mg/kg
body weight)
0.5-2.50.3512 – 603 – 15>2.5-50.7012 – 243 – 6>5-81.1212 – 19.23 – 4.8Over 8Use an appropriate combination of pipettes.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
For the treatment of roundworms and tapeworms a single administration per
treatment is effective.
For the treatment of queens to prevent lactogenic transmission of Toxocara cati (L3
larvae) to the offspring, a single administration per treatment approximately seven
days prior to expected parturition is effective.
For the lungworm Aelurostrongylus abstrusus, two treatments administered two
weeks apart are effective.
Method of administration
1. Remove the pipette from its packaging. Hold the pipette in an upright position,
twist and pull the cap off.
2. Turn the cap around and place the other end of the cap back on the pipette. Push
and twist the cap to break the seal, then remove the cap from the pipette.
3. Part the coat on the animal’s neck at the base of the skull until the skin is visible.
Place the tip of the pipette onto the skin and squeeze the pipette several times to
empty its contents completely and directly onto the skin in one spot. Avoid contact
between the veterinary medicinal product and your fingers.

Amended Pages: September 2025
Application at the base of the skull will minimise the opportunity for the animal to lick
the veterinary medicinal product off.
Do not use in kittens under 8 weeks of age or weighing less than 0.5 kg.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Cats:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Systemic disorders (anorexia, lethargy)
Digestive tract disorders (salivation, vomiting,
diarrhoea)
Neurological disorders (e.g. ataxia, tremor)
1,2,3
Behavioural disorders (e.g. hyperactivity, anxiety,
vocalisation)
Application site disorders (alopecia, pruritus
and/or inflammation)
1
As a result of the cat licking the application site immediately after treatment.
Mild signs.
Transient signs.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Shampooing or immersion of the animal in water directly after treatment may reduce
the efficacy of the veterinary medicinal product. Treated animals therefore should not
be bathed until the solution has dried.
In the absence of the risk of co-infection with nematodes and cestodes, a narrow
spectrum product should be used.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class.

Special precautions for safe use in the target species:
Apply only to the skin surface and on intact skin. Do not administer orally or
parenterally.
Avoid the treated cat or other cats in the household licking the site of application
while it is wet.
There is limited experience on the use of the veterinary medicinal product in sick and
debilitated animals, thus the veterinary medicinal product should only be used based
on a benefit-risk assessment for these animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Do not smoke, eat or drink during application.
Avoid direct contact with application area while it is wet. Keep children away from
treated animals during that time.
Once opened, use the entire contents of the pipette immediately.
Dispose of any used pipettes immediately after use.
Wash hands after use.
In case of accidental spillage onto skin, wash off immediately with soap and water.

Amended Pages: September 2025
If the veterinary medicinal product accidentally gets into eyes, they should be
thoroughly flushed with plenty of water.
If skin or eye symptoms persist, or in case of accidental ingestion, seek medical
advice immediately and show the package leaflet or the label to the physician.
Care should be taken not to allow children to have prolonged intensive contact (for
example, by sleeping) with treated cats during the first 24 hours after application of
the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
The solvent in this veterinary medicinal product may stain certain materials including
leather, fabrics, plastics and finished surfaces. Allow the application site to dry before
permitting contact with such materials.
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable
disease to the WOAH, specific guidelines on the treatment and follow-up, and on the
safeguard of persons, need to be obtained from the relevant competent authority.
Emodepside is a substrate for P-glycoprotein. Co-treatment with other drugs that are
P-glycoprotein substrates/inhibitors (for example, ivermectin and other antiparasitic
macrocyclic lactones, erythromycin, prednisolone and cyclosporine) could give rise to
pharmacokinetic drug interactions. The potential clinical consequences of such
interactions have not been investigated.
This veterinary medicinal product does not require any special temperature storage
conditions.
Store in the original packaging (PP pipettes inserted into laminated aluminium bags)
in order to protect from moisture.
Each 0.70 ml pipette contains:
Active substances:
Praziquantel 60 mg
Emodepside 15 mg
Excipients:
Qualitative composition of excipients
and other constituents
Quantitative composition if that
information is essential for proper
administration of the veterinary
medicinal product
Butylhydroxyanisole (E320)3.78 mg Isopropylidene glycerolLactic acid
Clear, colourless to yellow or to brown solution.
3. CLINICAL INFORMATION
3.1 Target species
Medium cats (> 2.5 – 5 kg).
3.2 Indications for use for each target species
For cats suffering from, or at risk from, mixed parasitic infections caused by
roundworms, tapeworms and lungworms of the following species:
Roundworms (Nematodes):
Toxocara cati (mature adult, immature adult, L4 and L3)
Toxocara cati (L3 larvae) – treatment of queens during late pregnancy to prevent
lactogenic transmission to the offspring
Toxascaris leonina (mature adult, immature adult and L4)
Ancylostoma tubaeforme (mature adult, immature adult and L4)

Amended Pages: September 2025
Tapeworms (Cestodes):
Dipylidium caninum (mature adult and immature adult)
Taenia taeniaeformis (adult)
Echinococcus multilocularis (adult)
Lungworms:
Aelurostrongylus abstrusus
The veterinary medicinal product is only indicated when use against nematodes and
cestodes is indicated at the same time.
3.3 Contraindications
Do not use in kittens under 8 weeks of age or weighing less than 0.5 kg.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
3.4 Special warnings
Shampooing or immersion of the animal in water directly after treatment may reduce
the efficacy of the veterinary medicinal product. Treated animals therefore should not
be bathed until the solution has dried.
In the absence of the risk of co-infection with nematodes and cestodes, a narrow
spectrum product should be used.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class.
3.5 Special precautions for use
Special precautions for safe use in the target species:
Apply only to the skin surface and on intact skin. Do not administer orally or
parenterally.
Avoid the treated cat or other cats in the household licking the site of application
while it is wet.
There is limited experience on the use of the veterinary medicinal product in sick and
debilitated animals, thus the veterinary medicinal product should only be used based
on a benefit-risk assessment for these animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Do not smoke, eat or drink during application.
Avoid direct contact with application area while it is wet. Keep children away from
treated animals during that time.
Once opened, use the entire contents of the pipette immediately.
Dispose of any used pipettes immediately after use.
Wash hands after use.
In case of accidental spillage onto skin, wash off immediately with soap and water.

Amended Pages: September 2025
If the veterinary medicinal product accidentally gets into eyes, they should be
thoroughly flushed with plenty of water.
If skin or eye symptoms persist, or in case of accidental ingestion, seek medical
advice immediately and show the package leaflet or the label to the physician.
Care should be taken not to allow children to have prolonged intensive contact (for
example, by sleeping) with treated cats during the first 24 hours after application of
the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
The solvent in this veterinary medicinal product may stain certain materials including
leather, fabrics, plastics and finished surfaces. Allow the application site to dry before
permitting contact with such materials.
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable
disease to the WOAH, specific guidelines on the treatment and follow-up, and on the
safeguard of persons, need to be obtained from the relevant competent authority.
3.6 Adverse events
Cats:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Systemic disorders (anorexia, lethargy)
Digestive tract disorders (salivation, vomiting,
diarrhoea)
Neurological disorders (e.g. ataxia, tremor)
1,2,3
Behavioural disorders (e.g. hyperactivity, anxiety,
vocalisation)
Application site disorders (alopecia, pruritus
and/or inflammation)
1
As a result of the cat licking the application site immediately after treatment.
Mild signs.
Transient signs.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
3.7 Use during pregnancy, lactation or lay
Pregnancy and lactation:
Can be used during pregnancy and lactation. See section 3.9.

Amended Pages: September 2025
3.8 Interaction with other medicinal products and other forms of interaction
Emodepside is a substrate for P-glycoprotein. Co-treatment with other drugs that are
P-glycoprotein substrates/inhibitors (for example, ivermectin and other antiparasitic
macrocyclic lactones, erythromycin, prednisolone and cyclosporine) could give rise to
pharmacokinetic drug interactions. The potential clinical consequences of such
interactions have not been investigated.
3.9 Administration routes and dosage
Spot-on use for external application to the skin.
Dosage and Treatment Schedule
The recommended minimum doses are 12 mg praziquantel / kg body weight and 3
mg emodepside / kg body weight, equivalent to 0.14 ml of the veterinary medicinal
product / kg body weight.
Body weight
of the cat
(kg)
Pipette size/volume
(ml) to be used
Praziquantel (mg/kg
body weight)
Emodepside (mg/kg
body weight)
0.5-2.50.3512 – 603 – 15>2.5-50.7012 – 243 – 6>5-81.1212 – 19.23 – 4.8Over 8Use an appropriate combination of pipettes.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
For the treatment of roundworms and tapeworms a single administration per
treatment is effective.
For the treatment of queens to prevent lactogenic transmission of Toxocara cati (L3
larvae) to the offspring, a single administration per treatment approximately seven
days prior to expected parturition is effective.
For the lungworm Aelurostrongylus abstrusus, two treatments administered two
weeks apart are effective.
Method of administration
1. Remove the pipette from its packaging. Hold the pipette in an upright position,
twist and pull the cap off.
2. Turn the cap around and place the other end of the cap back on the pipette. Push
and twist the cap to break the seal, then remove the cap from the pipette.
3. Part the coat on the animal’s neck at the base of the skull until the skin is visible.
Place the tip of the pipette onto the skin and squeeze the pipette several times to
empty its contents completely and directly onto the skin in one spot. Avoid contact
between the veterinary medicinal product and your fingers.

Amended Pages: September 2025
Application at the base of the skull will minimise the opportunity for the animal to lick
the veterinary medicinal product off.
3.10 Symptoms of overdose (and where applicable, emergency procedures and
antidotes)
Salivation, vomiting and neurological signs (tremor) were observed occasionally
when the veterinary medicinal product was administered at up to 10 times the
recommended dose in adult cats and up to 5 times the recommended dose in kittens.
These symptoms were thought to occur as a result of the cat licking the application
site. The symptoms were completely reversible.
There is no known specific antidote.
3.11 Special restrictions for use and special conditions for use, including
restrictions on the use of antimicrobial and antiparasitic veterinary medicinal
products in order to limit the risk of development of resistance
Not applicable.
3.12 Withdrawal periods
Not applicable.
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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