Pramilon 12.5 mg/125 mg Film-coated Tablets for Dogs

In order to develop an effective worm control programme, local epidemiological
information and the living conditions of the dog should be taken into account and
therefore it is recommended to seek professional advice.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class.
It is recommended to treat all the animals in the same household concomitantly.
When infection is present, concomitant treatment against
intermediate hosts, such as fleas and lice, should be considered to prevent re-infection.

Revised July 2025

Special precautions for safe use in the target species:
Studies with milbemycin oxime indicate that the margin of safety in certain dogs of
Collie or related breeds is less than in other breeds. In these dogs, the recommended
dose should be strictly observed.
The tolerance of the veterinary medicinal product in young puppies from these breeds
has not been investigated.
Clinical signs in Collies are similar to those seen in the general dog population when
overdosed (see also section 3.10).
As per good veterinary practice, animals should be weighed to ensure accurate dosing.
Treatment of dogs with a high number of circulating microfilariae can sometimes lead to
the appearance of hypersensitivity reactions, such as pale mucous membranes,
vomiting, trembling, laboured breathing or excessive salivation. These reactions are
associated with the release of proteins from dead or dying microfilariae and are not a
direct toxic effect of the veterinary medicinal product. The use in dogs suffering from
microfilaremia is thus not recommended.
In heartworm risk-areas, or in the case it is known that a dog has been travelling to and
from heartworm risk regions, before using the veterinary medicinal product, a veterinary
consultation is advised to exclude the presence of any concurrent infestation of
Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated
before administering the veterinary medicinal product.
No studies have been performed with severely debilitated dogs or individuals with
seriously compromised kidney or liver function. The veterinary medicinal product is not
recommended for such animals or only according to the benefit-risk assessment by the
responsible veterinarian.
In dogs less than 4 weeks old, tapeworm infection is unusual. Treatment of animals less
than 4 weeks old with a combination product may therefore not be necessary.
The tablets are flavoured. In order to avoid any accidental ingestion, store tablets out of
reach of the animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Wash hands after use.
In case of accidental ingestion of the tablets, particularly by a child, seek medical advice
immediately and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.

Revised July 2025
Other precautions:
Echinococcosis represents a hazard for humans. As echinococcosis is a notifiable
disease to the World Organisation for Animal Health (WOAH), specific guidelines on the
treatment and follow-up, and on the safeguard of persons, need to be obtained from the
relevant competent authority.