Paxcutol 2.5875% w/v Shampoo

Not applicable
5. PHARMACOLOGICAOL PROPERTIES
ATC vet: QD11AX10

Revised: 08 September 2009
AN: 02108/2008
Paxcutol Shampoo is an antibacterial and keratolytic preparation for use on dogs.
It contains as active ingredient 2.5875 % w/v benzoyl peroxide, and oxidating
substance.
5.1 Pharmacodynamic properties
Benzoyl peroxide, when applied on the skin, decomposes releasing benzoyl
peroxy radicals and nascent oxygen, after interacting with biological substances,
thermal variation and ultra-violet exposure. When the free radicals are formed,
reactions such as interactions with (-OH) hydroxyl and (-SH) sulfhydryl groups,
double bonds and aromatic compounds occur. The results of these interactions
disrupt the membranes of bacterial cells, altering permeability of the membrane
and, subsequently, the function of the cell. It is therefore indicated for the
treatment of topical ailments involving bacterial infections. Additionally, benzoyl
peroxide reduces the activity of seborrheic glands, contributing to resolving
seborrhoeic conditions.
5.2 Pharmacokinetic properties

Benzoyl peroxide reacts rapidly with cysteine, an integral amino acid contained in
keratin. In reacting with cysteine, benzoyl peroxide is rapidly reduced to benzoic
acid and various benzoate salts which do not penetrate the skin and are
biologically harmless. The interaction of benzoyl peroxide with skin is usually of
no untoward consequence.