Panacur Bolus 12 g, Continuous Release Intraruminal Device for Cattle

If an intraruminal device treated animal is sold during the season, the purchaser
must be informed of the date on which the intraruminal device was administered.
The intraruminal device can interfere with the detection of foreign bodies (hardware
disease) by an electronic metal detector.
Immunity to nematodes depends on adequate exposure to infection. Although not
normally the case, circumstances could occur in which anthelmintic control
measures might increase the vulnerability of cattle to re-infection. Animals may be at
risk towards the end of their first grazing season, particularly if the season is long, or
in the following year if they are moved onto heavily contaminated pasture. In such
circumstances, further control measures may be necessary.
Where specific preventative control of lungworm is required, it is advised that cattle
are given an appropriate lungworm vaccine. As the veterinary medicinal product
allows a small percentage of lungworm to reach the lungs when cattle are exposed,
it will not interfere with the development of immunity.
Under conditions of heavy larval challenge, clinical signs of lungworm may become
evident. Therefore, if clinical signs of lungworm occur in treated cattle they should
be dosed immediately with an appropriate anthelmintic. Without additional control
measures, such as vaccination, lungworm infestations can sometimes occur during
the life of the intraruminal device.
Intensive use or misuse of anthelmintics can give rise to resistance. To reduce this
risk dosing programmes should be discussed with veterinary surgeon.
Care should be taken to avoid the following practices because they increase the risk
of development of resistance and could ultimately result in ineffective therapy:
•
extended period of time.
•
misadministration of the product, or lack of calibration of the dosing device (if
any).
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used.
Resistance to benzimidazoles has been reported in Teladorsagia, Haemonchus,
Cooperia and Trichostrongylus species in small ruminants.
Therefore, the use of this product should be based on local (regional, farm)
epidemiological information about susceptibility of nematodes and recommendations
on how to limit further selection for resistance to anthelmintics.

Special precautions for safe use in the target species:
Administer the intraruminal device gently and with great care.
In very rare cases, mild to severe oesophageal lesions might occur if the product is
not used as recommended.
If lungworm vaccination is practised in cattle before turnout, the intraruminal device
should not be administered until 14 days after the second dose of vaccine has been
given.
Ensure all animals weigh more than 100 kg body weight. Do not administer
concurrently with other medicinal intraruminal devices.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Direct contact with the skin should be kept to a minimum. Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.