Onsior 6 mg Tablets for Cats

This veterinary medicinal product must not be administered in conjunction with
other NSAIDs or glucocorticosteroids. Pre-treatment with other anti-
inflammatory medicines may result in additional or increased adverse effects
and, accordingly, a treatment-free period with such substances should be
observed for at least 24 hours before the commencement of treatment with this
veterinary medicinal product. The treatment-free period, however, should take
into account the pharmacokinetic properties of the products used previously.
Concomitant treatment with medicines displaying action on renal flow, e.g.
diuretics or angiotensin- converting enzyme (ACE) inhibitors, should be subject
to clinical monitoring.

Issued: October 2023
AN: 02941/2022
In healthy cats treated with or without the diuretic furosemide, concomitant
administration of this veterinary medicinal product with the ACE inhibitor
benazepril for 7 days was not associated with any negative effects on plasma
aldosterone concentrations, plasma renin activity or glomerular filtration rate.
No safety data in the target population and no efficacy data in general exist for
the combined treatment of robenacoxib and benazepril.
As anaesthetics may affect renal perfusion, the use of parenteral fluid therapy
during surgery should be considered to decrease potential renal complications
when using NSAIDs peri-operatively.
Concurrent administration of potentially nephrotoxic medicines should be
avoided as there might be an increased risk of renal toxicity.
Concurrent use of other active substances that have a high degree of protein
binding may compete with robenacoxib for binding and thus lead to toxic
effects.