On-Defence Wormer 50 mg/144 mg/150 mg Film-coated Tablets for Dogs
Active ingredients: Febantel, Praziquantel, Pyrantel Embonate
Form
Tablet
Species
Manufacturer
C&H Generics Ltd
VMD MA No.
40162/4031
What it's used for
For the treatment of mixed infections with roundworms, hookworms, whipworms, and tapeworms of the following species: Roundworms (Nematodes): Ascarids (adul...
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On-Defence Wormer 50 mg/144 mg/150 mg Film-coated Tablets for Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
tapeworms of the following species:
Roundworms (Nematodes):
Ascarids (adult and late immature forms): Toxocara canis, Toxascaris leonina.
Hookworms (adults): Uncinaria stenocephala, Ancylostoma caninum.
Whipworms (adults): Trichuris vulpis.
Tapeworms (Cestodes):
Adult and immature forms of: Echinococcus species (E. granulosus, E.
multilocularis), Taenia (T. hydatigena, T. pisiformis, T. taeniformis),
Dipylidium caninum.
Revised: March 2022
AN: 01607/2021
To ensure administration of a correct dose, body weight should be determined as
accurately as possible.
Dosage:
1 tablet per 10 kg (22 lbs) bodyweight.
This is equivalent to 15 mg febantel, 14.4 mg pyrantel embonate and 5 mg
praziquantel per kilo bodyweight.
It is important to follow the treatment recommendations as presented here. Do not
deviate from the recommendations without the advice of your veterinary surgeon.
Revised: March 2022
AN: 01607/2021
Dosage table:
Bodyweight (kg)Tablets3.0-5.0½>5.0-7.5¾ >7.5-10.01>10.0-15.01½>15.0-20.02>20.0-25.02½>25.0-30.03>30.0-35.03½>35.0-40.04>40.01 tablet per 10 kg
Administration and Duration of Treatment
The tablets can be given directly to the dog or disguised in food. No starvation is
needed before or after treatment.
Not for use in dogs weighing less than 3 kg or less than 2 weeks of age.
Puppies should be treated at 2 weeks of age and every 2 weeks until 12 weeks of
age.
Thereafter they should be treated at 3-month intervals. It is advisable to treat the
bitch at the same time as the puppies.
For routine worm control, adult dogs should be treated with a single dose every 3
months.
For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving
birth and every two weeks until weaning.
In case of suspected heavy roundworm infestation, please contact your veterinary
surgeon for diagnosis and treatment recommendations.
If there is a risk of re-infestation (see section 4.4), the advice of a veterinarian should
be sought regarding the need for and the frequency of repeat administration.
excipients.
Do not use simultaneously with piperazine compounds as piperazine may block the
action of pyrantel embonate contained in this product. Other worming products may
contain piperazine.
Do not use simultaneously with other deworming products without veterinary advice.
Do not exceed the stated dose.
and/or diarrhoea may occur. In individual cases these signs can be accompanied by
nonspecific signs such as lethargy, anorexia, or hyperactivity.
Revised: March 2022
AN: 01607/2021
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- Common (more than 1 but less than 10 animals in 100 animals treated)
- Uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- Rare (more than 1 but less than 10 animals in 10,000 animals treated)
- Very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
caninum. Tapeworm infestation is certain to reoccur unless control of intermediate
hosts such as fleas, mice, etc. is undertaken.
Dogs should also be prevented from scavenging or hunting as part of measures to
prevent tapeworm reinfestation.
If your dog receives other veterinary medicinal products, check with a veterinary
surgeon or pharmacist before using this product.
Tapeworm infestation is unlikely in pups less than 6 weeks of age.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class.
Special precautions for use in animals
Do not exceed the stated dose, especially when treating pregnant bitches.
To ensure administration of a correct dose, body weight should be determined as
accurately as possible.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
In case of accidental ingestion, seek medical advice and show the package leaflet to
the physician.
In the interests of good hygiene, persons administering the tablets either directly to
the dog, or by adding them to the dog's food, should wash their hands afterwards.
Other precautions
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable
disease to the World Organisation for Animal Health (OIE), specific guidelines on the
treatment and follow-up, and on the safeguard of persons, need to be obtained from
the relevant competent authority.
pyrantel and piperazine may be antagonized (see section 4.3).
Concurrent use with other cholinergic compounds (e.g. neostigmine, propoxur, and
bethanechol) can lead to toxicity.
The tablets can be given directly to the dog or disguised in food. No starvation is
needed before or after treatment.
Not for use in dogs weighing less than 3 kg or less than 2 weeks of age.
Puppies should be treated at 2 weeks of age and every 2 weeks until 12 weeks of
age.
Thereafter they should be treated at 3-month intervals. It is advisable to treat the
bitch at the same time as the puppies.
For routine worm control, adult dogs should be treated with a single dose every 3
months.
For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving
birth and every two weeks until weaning.
In case of suspected heavy roundworm infestation, please contact your veterinary
surgeon for diagnosis and treatment recommendations.
If there is a risk of re-infestation (see section 4.4), the advice of a veterinarian should
be sought regarding the need for and the frequency of repeat administration.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The combination of praziquantel, pyrantel embonate and febantel is well tolerated in
dogs. In safety studies, a single dose of 5 times the recommended dose or greater
gave rise to occasional vomiting.
Revised: March 2022
AN: 01607/2021
4.11 Withdrawal period
Not applicable.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Febantel
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Anthelmin Plus Flavour Tablets for Dogs
NFA-VPSKRKA, d.d., Novo mesto
Anthelmin Plus XL Tablets for Dogs
NFA-VPSKRKA, d.d., Novo mesto
Avicas, Febantel 15 mg, Tablet
AVM-GSLOropharma n.v
Beaphar WORMclear Tablets for Dogs
AVM-GSLC&H Generics Ltd
Bob Martin Clear 3 in 1 Flavoured Wormer 150/144/50 mg Tablets for Dogs
AVM-GSLVetoquinol UK Limited
Bob Martin Clear 3 in 1 Flavoured Wormer XL 525/504/175 mg Tablets for Large Dogs
AVM-GSLVetoquinol UK Limited
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