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POM-V Prescription Required Companion Animal

Numelvi 31.6 mg Tablets for Dogs

Active ingredient: Atinvicitinib

Form

Tablet

Species

Dogs

Manufacturer

MSD Animal Health UK Limited

VMD MA No.

01708/5137

What it's used for

For the treatment of the clinical manifestations associated with atopic dermatitis in dogs, including pruritus.

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Atinvicitinib

  1. 1

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    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Numelvi 31.6 mg Tablets for Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For the treatment of the clinical manifestations associated with atopic dermatitis in
dogs, including pruritus.
The veterinary medicinal product should be administered once daily at the
recommended dose of 0.8 to 1.2 mg atinvicitinib/kg bodyweight at or around the time
of feeding, in accordance with the following dosing table. Doses in the table,
achieved within each weight band, correspond to the recommended dose of
atinvicitinib in milligrams per kilogram bodyweight:
Strength and number of tablets to be
administered
Bodyweight
of dog (kg)
Numelvi
4.8 mg
Numelvi
7.2 mg
Numelvi
21.6 mg
Numelvi
31.6 mg
3.0 - 4.3½4.4 - 6.016.1 - 9.019.1 - 13.5½13.6 - 19.3½19.4 - 26.5126.6 - 39.5139.6 - 54.01 ½54.1 - 79.02
The tablets are breakable along the score line.
Dogs outside the listed weight bands, for example dogs above 79 kg bodyweight, can
be dosed with a combination of full and/or half tablets of the appropriate tablet
strengths to achieve a target dose of 0.8 to 1.2 mg atinvicitinib/kg bodyweight (see
SPC section 3.5). However, the available tablet strengths do not allow for accurate
dosing of dogs weighing less than 2 kg bodyweight.
The intensity and duration of pruritus associated with allergic dermatitis and the
clinical manifestations of atopic dermatitis are variable. The need for long-term
treatment of dogs receiving the veterinary medicinal product should be based on an
individual benefit-risk assessment.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Dogs:
Common
(1 to 10 animals / 100 animals
treated):
Emesis, diarrhoea.
Lethargy, anorexia.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
None.

Special precautions for safe use in the target species:
Safety of this veterinary medicinal product has not been investigated in dogs younger
than 6 months of age. Use of the veterinary medicinal product in younger animals
should be based on a benefit-risk assessment by the responsible veterinarian.
Complicating factors such as bacterial, fungal or parasitic infections (e.g., fleas,
Demodex mites), in addition to any underlying causes of allergic and atopic
dermatitis (e.g., flea allergy, contact allergy, food allergy) should be investigated and
treated.
Use of the veterinary medicinal product has not been evaluated in combination with
systemic immunosuppressive agents such as glucocorticoids, cyclosporine or other
immunosuppressive agents. Furthermore, the safety of the veterinary medicinal
product has not been investigated in dogs with evidence of immunosuppression (for
example, uncontrolled primary hypothyroidism, rickettsial disease) or dogs with
evidence of progressive malignant neoplasia. Use in such cases should be based on
a benefit-risk assessment by the responsible veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Wash hands thoroughly with soap and water immediately after use of the veterinary
medicinal product.
Special precautions for the protection of the environment:
Not applicable.
No drug interactions were observed in field studies where the veterinary medicinal
product was administered concomitantly with other veterinary medicinal products
such as antimicrobials (including topical preparations), ecto- and endoparasiticides
(isoxazolines, milbemycins, avermectins, pyrethrins and pyrethroids), nutritional
supplements, topical skin and ear cleansers that did not contain glucocorticoids, and
medicated shampoos.
The user is also referred to section 3.5 of the SPC (special precautions for safe use
in the target species) for additional guidance.
In a controlled laboratory study, a similar serological response to vaccination with
modified live canine adenovirus type-2 (CAV), canine distemper virus (CDV), canine
parvovirus (CPV) and inactivated rabies virus (RV) was observed when 6-month-old
vaccine naïve puppies were administered the veterinary medicinal product at 3.6
mg/kg atinvicitinib (3 times the maximum labelled dose) once daily for 84 days,
compared to dogs receiving the vaccines alone. The veterinary medicinal product
was well-tolerated with no adverse clinical effects related to treatment when used
concomitantly with vaccination.
This veterinary medicinal product does not require any special storage conditions.
Any remaining half tablet should be placed back into the opened blister or into the
bottle.
Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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