Milprazon 4 mg/10 mg Film-Coated Tablets for Small Cats and Kittens Weighing at Least 0.5 kg
Active ingredients: Milbemycin Oxime (A3 and A4), Praziquantel
Form
Tablet
Species
Manufacturer
KRKA, d.d., Novo mesto
VMD MA No.
01656/5077
What it's used for
Echinococcus multilocularis - Nematodes: Ancylostoma tubaeforme Toxocara cati Prevention of heartworm disease (Dirofilaria immitis) if concomitant treatmen...
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Milprazon 4 mg/10 mg Film-Coated Tablets for Small Cats and Kittens Weighing at Least 0.5 kg — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
- Nematodes:
Ancylostoma tubaeforme
Toxocara cati
Prevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against
cestodes is indicated.
possible.
Minimum recommended dose rate: 2 mg of milbemycin oxime and 5 mg of
praziquantel per kg are given orally as a single dose. The veterinary medicinal
product should be administered with or after some food. Doing so ensures optimum
protection against heartworm disease.
Depending on the bodyweight of the cat, the practical dosing is as follows:
Body weightFilm-coated tablets for
small cats and kittens
0.5 - 1 kg½ tablet> 1 - 2 kg1 tablet
The veterinary medicinal product can be inserted into a programme for prevention of
heartworm disease if at the same time treatment against tapeworms is indicated. For
the prevention of heartworm disease: the veterinary medicinal product kills Dirofilaria
immitis larvae up to one month after their transmission by mosquitoes. For regular
prevention of heartworm disease the use of a monosubstance is preferred.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reaction;
Systemic disorder (e.g. lethargy)*;
Neurological disorder (e.g. muscle tremors and
ataxia)*;
Digestive tract disorder (e.g. emesis and
diarrhoea)*.
*Especially in young cats.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
concomitantly.
In order to develop an effective worm control programme local epidemiological
information and the risk of exposure of the cat should be taken into account, and it is
recommended to seek professional advice.
When D. caninum infection is present, concomitant treatment against intermediate
hosts, such as fleas and lice, should be considered to prevent re-infection.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class.
Special precautions for safe use in the target species:
No studies have been performed with severely debilitated cats or individuals with
seriously compromised kidney or liver function. The veterinary medicinal product is
not recommended for such animals or only according to a benefit/risk assessment by
the responsible veterinarian.
Ensure cats and kittens weighing between 0.5 kg and ≤2 kg receive the appropriate
tablet strength (4 mg milbemycin oxime/10 mg praziquantel) and the appropriate
dose (1/2 or 1 tablet) for the corresponding weight band (1/2 tablet for cats weighing
0.5 to 1 kg; 1 tablet for cats weighing >1 to 2 kg).
As the tablets are flavoured, they should be stored in a safe place out of the reach of
animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
People with known hypersensitivity to the active substances or the excipients should
avoid contact with the veterinary medicinal product.
In the event of accidental ingestion of the tablets, particularly by a child, seek medical
advice immediately and show the package leaflet or the label to the physician.
Wash hands after use.
Part tablets should be returned to the open blister pocket and inserted into the outer
carton.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable
disease to the World Organisation for Animal Health (WOAH), specific guidelines on
the treatment and follow-up, and on the safeguard of persons, need to be obtained
from the relevant competent authority.
lactone selamectin was administered during treatment with milbemycin oxime and
praziquantel at the recommended dose.
Although not recommended, the concomitant use of milbemycin oxime and
praziquantel with a spot-on containing moxidectin and imidacloprid at recommended
dose rates following a single application was well tolerated in one laboratory study in
10 kittens.
The safety and efficacy of the concurrent use have not been investigated in field
studies.
In the absence of further studies, caution should be taken in the case of concurrent
use of the veterinary medicinal product and other macrocyclic lactones. Also, no such
studies have been performed with reproducing animals.
Halved tablets should be stored below 25°C in the original blister and be used for the
next administration.
Keep the blister in the outer carton.
4.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Milbemycin Oxime (A3 and A4)
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Aderexa 12.5 mg/125 mg Chewable Tablets for Dogs Weighing at Least 5 kg
POM-VKRKA, d.d., Novo mesto
Aderexa 2.5 mg/25 mg Chewable Tablets for Small Dogs and Puppies Weighing at Least 0.5 kg
POM-VKRKA, d.d., Novo mesto
Alpramil 12 mg/30 mg Film-coated Tablets for Cats Weighing at Least 3 kg
POM-VAlfasan Nederland B.V.
Alpramil 12 mg/30 mg Film-coated Tablets for Cats Weighing at Least 3 kg
POM-VAlfasan Nederland B.V.
Alpramil 12.5 mg/125 mg Tablets for Dogs Weighing at Least 5 kg
POM-VAlfasan Nederland B.V.
Alpramil 12.5 mg/125 mg Tablets for Dogs Weighing at Least 5 kg
POM-VAlfasan Nederland B.V.
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