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POM-V Prescription Required Companion Animal

Milbeguard Duo 16 mg / 40 mg Film-coated Tablets for Cats

Active ingredients: Milbemycin Oxime (A3 and A4), Praziquantel

Form

Tablet

Species

Cats

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/5013

What it's used for

In cats: treatment of mixed infections by immature and adult cestodes and nematodes of the following species: - Cestodes: Dipylidium caninum Taenia . Echin...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Prescription required

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Clinical information

Milbeguard Duo 16 mg / 40 mg Film-coated Tablets for Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

In cats: treatment of mixed infections by immature and adult cestodes and nematodes
of the following species:
- Cestodes:
Dipylidium caninum
Taenia .
Echinococcus multilocularis
- Nematodes:
Ancylostoma tubaeforme
Toxocara cati
Prevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against
cestodes is indicated.

Revised: September 2025
AN: 01835/2025
Do not use in cats weighing less than 2 kg.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Cats:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reaction
Lethargy
, Anorexia
Muscle tremor, Ataxia
Emesis
, Diarrhoea
1
: especially in young cats
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy. The
decision to use the product should be based on confirmation of the parasitic species
and burden, or of the risk of infection based on its epidemiological features, for each
individual animal.
It is recommended to treat all the animals living in the same household concomitantly.
When infection with the cestode has been confirmed, concomitant
treatment against intermediate hosts, such as fleas and lice, should be discussed with
a veterinarian to prevent re-infection.
The use of this product should take into account local information about susceptibility
of the target parasites, where available.
In the absence of risk of co-infection with nematodes or cestodes, a narrow spectrum
product should be used when available.

i). Special precautions for use in animals
Ensure cats and kittens weighing between 0.5 kg and
of the 4/10 mg strength tablet.
No studies have been performed with severely debilitated cats or individuals with
seriously compromised kidney or liver function. The product is not recommended for
such animals or only according to a benefit/risk assessment by the responsible
veterinarian.
The tablets are flavoured. In order to avoid any accidental ingestion, store tablets out
of reach of the animals.
ii). Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This veterinary medicinal product may be harmful when ingested, particularly for
children. To avoid accidental ingestion, the product should be stored out of sight and
reach of children. Any unused part of tablet should be stored in the opened blister,
inside the outer packaging and always be used at the next administration.
In the event of accidental ingestion of the tablets, particularly by a child, seek medical
advice immediately and show the package leaflet or the label to the physician.
Wash hands after use.
iii). Other precautions
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable
disease to the World Organisation for Animal Health (OIE), specific guidelines on the
treatment and follow up and on the safeguard of persons need to be obtained from the
relevant competent authority.

Revised: September 2025
AN: 01835/2025
The concurrent use of the product with selamectin is well tolerated. No interactions
were observed when the recommended dose of the macrocyclic lactone selamectin
was administered during the treatment with the product at the recommended dose.
Although not recommended, the concomitant use of the product with a spot-on
containing moxidectin and imidacloprid at recommended dose rates following a single
application was well tolerated in one laboratory study in 10 kittens.
The safety and efficacy of the concurrent use have not been investigated in field
studies. In the absence of further studies, caution should be taken in the case of
concurrent use of the product with any other macrocyclic lactone. Also, no such studies
have been performed with reproducing animals.
This veterinary medicinal product does not require any special storage conditions.
Halved tablets should be stored in the original blister and be used for the next
administration.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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