Felimazole

In order to enhance stabilisation of the hyperthyroid patient the same feeding and
dosing schedule should be used daily.

Special precautions for safe use in the target species:
If more than 10 mg per day is required animals should be monitored particularly
carefully.
Use of the product in cats with renal dysfunction should be subject to careful
risk:benefit assessment by the clinician. Due to the effect thiamazole can have on
reducing the glomerular filtration rate, the effect of therapy on renal function should be
monitored closely as deterioration of an underlying condition may occur.
Haematology must be monitored due to risk of leucopenia or haemolytic anaemia.
Any animal that suddenly appears unwell during therapy, particularly if they are febrile,
should have a blood sample taken for routine haematology and biochemistry.
Neutropenic animals (neutrophil counts <2.5 x 10
/l) should be treated prophylactically
with bactericidal antibiotics and supportive therapy, if needed, according to the benefit-
risk assessment of the prescribing veterinarian.
Please refer to section 3.9 for monitoring instructions.
As thiamazole can cause haemoconcentration, cats should always have access to
drinking water.
In hyperthyroid cats, gastrointestinal disorders are common and may interfere with the
success of the oral therapy.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
People with known hypersensitivity (allergy) to thiamazole or vanillin should avoid
contact with the veterinary medicinal product. If allergic symptoms develop, such as a
skin rash, swelling of the face, lips or eyes or difficulty in breathing, you should seek
medical attention immediately and show the package leaflet or label to the doctor.
Thiamazole may cause gastrointestinal disturbances, headache, fever, joint pain,
pruritus (itching) and pancytopaenia (decrease in blood cells and platelets).
The product may also cause skin irritation.
Avoid dermal and oral exposure, including hand-to-mouth contact.
Do not eat, drink or smoke while handling the product or used litter.
Wash hands with soap and water after administration and handling of the product and
cleaning the vomit of, or litter used by, treated animals. Wash any spillages or splatter
from skin immediately.
Following administration of the product any residual product remaining on the tip of
the dosing syringe should be wiped clean with a tissue. The contaminated tissue
should be immediately disposed of.
The used syringe should be stored with the product in the original carton.
Do not leave filled syringes unattended. In case of accidental ingestion, seek medical
advice immediately and show the package leaflet or the label to the physician.
This product may cause eye irritation.
Avoid eye contact including hand to eye contact.
AN: 01911/2024 & 01915/2024
In case of accidental eye contact, rinse eyes immediately with clean running water. If
irritation develops, seek medical advice.
As thiamazole is a suspected human teratogen, women of child-bearing age
must wear non-permeable single-use gloves when administering the product or
handling the litter/vomit of treated cats.
If you are pregnant, think you may be pregnant or are attempting to conceive,
you should not administer the product or handle the litter/vomit of treated cats.
Special precautions for the protection of the environment:
Not applicable.