Elanco Milbemycin - Praziquantel 2.5 mg/25 mg Tablets for Small Dogs and Puppies

It is recommended to treat all the animals living in the same household concomitantly.
When infection with the cestode has been confirmed, concomitant
treatment against intermediate hosts, such as fleas and lice, should be discussed with
a veterinarian to prevent re-infection.
Studies with milbemycin oxime indicate that the margin of safety in certain dogs of
Collie or related breeds is less than in other breeds. In these dogs, the recommended
dose should be strictly observed.
The tolerance of Elanco Milbemycin - Praziquantel
dogs and puppies in young puppies from these breeds has not been investigated.
Clinical signs in Collies are similar to those seen in the general dog population when
overdosed (see section 4.10).

Special precautions for use in animals
As per good veterinary practice, animals should be weighed to ensure accurate
dosing
Treatment of dogs with a high number of circulating microfilariae can sometimes lead
to the appearance of hypersensitivity reactions, such as pale mucous membranes,
vomiting, trembling, laboured breathing or excessive salivation. These reactions are
associated with the release of proteins from dead or dying microfilariae and are not a
direct toxic effect of the product. The use in dogs suffering from microfilaremia is thus
not recommended.
In heartworm risk-areas, or in the case it is known that a dog has been travelling to
and from heartworm risk regions, before using Elanco Milbemycin - Praziquantel 2.5
mg/12.5 mg tablets for small dogs and puppies, a veterinary consultation is advised
to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the
case of a positive diagnosis, adulticidal therapy is indicated before administering
Elanco Milbemycin - Praziquantel 2.5 mg/12.5 mg tablets for small dogs and puppies.
Echinococcosis represents a hazard for humans. In case of Echinococcosis, specific
guidelines on the treatment and follow up and on the safeguard of persons have to
be followed. Experts or institutes of parasitology should be consulted.

Issued: December 2022
AN: 00872/2022
No studies have been performed with severely debilitated dogs or individuals with
seriously compromised kidney or liver function. The product is not recommended for
such animals or only according to a benefit/risk assessment by the responsible
veterinarian.
In dogs less than 4 weeks old, tape worm infection is unusual. Treatment of animals
less than 4 weeks old with a combination product may therefore not be necessary.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Wash hands after use.
In case of accidental ingestion of the tablets, particularly by a child, seek medical
advice immediately and show the package leaflet or the label to the physician.