Dexmedocord 0.5 mg/ml Solution for Injection
Active ingredient: Dexmedetomidine Hydrochloride
Form
Injection
Species
Manufacturer
Accord Healthcare B.V
VMD MA No.
42153/3006
What it's used for
Deep sedation and analgesia in dogs in concomitant use with butorphanol for medical and minor surgical procedures. Premedication in dogs and cats before in...
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Dexmedocord 0.5 mg/ml Solution for Injection — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
and minor surgical procedures.
Premedication in dogs and cats before induction and maintenance of general
anaesthesia.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Dosage: the following doses are recommended:
DOGS:
Dexmedetomidine doses are based on body surface area:
Intravenously: up to 375 micrograms/square metre body surface area
Intramuscularly: up to 500 micrograms/square metre body surface area
When administering in conjunction with butorphanol (0.1 mg/kg) for deep sedation and
analgesia, the intramuscular dose of dexmedetomidine is 300 micrograms/square
metre body surface area. The premedication dose of dexmedetomidine is 125–375
micrograms/square metre body surface area, administered 20 minutes prior to
induction for procedures requiring anaesthesia. The dose should be adjusted to the
type of surgery, length of procedure and patient temperament.
Concomitant use of dexmedetomidine and butorphanol produces sedative and
analgesic effects beginning no later than 15 minutes. The peak sedative and analgesic
effects are reached within 30 minutes after administration. Sedation lasts for at least
120 minutes post administration and analgesia lasts for at least 90 minutes.
Spontaneous recovery occurs within 3 hours.
Premedication with dexmedetomidine will significantly reduce the dosage of the
induction agent required and will reduce volatile anaesthetic requirements for
maintenance anaesthesia. In a clinical study, the requirement for propofol and
thiopental was reduced by 30% and 60% respectively. All anaesthetic agents used for
induction or maintenance of anaesthesia should be administered to effect. In a clinical
study, dexmedetomidine contributed to postoperative analgesia for 0.5–4 hours.
However this duration is dependent on a number of variables and further analgesia
should be administered in accordance with clinical judgement.
The corresponding doses based on body weight are presented in the following tables.
Use of an appropriately graduated syringe is recommended to ensure accurate dosing
when administering small volumes.
Dog
weight
Dexmedetomidine
125 mcg/m
Dexmedetomidine
375 mcg/m
Dexmedetomidine
500 mcg/m
(kg)(mcg/kg)(mL)(mcg/kg)(mL)(mcg/kg)(mL)2-39.40.0428.10.12400.153-48.30.05250.17350.24-57.70.07230.2300.35-106.50.119.60.29250.410-135.60.1316.80.38230.513-155.20.1515.70.44210.615-204.90.1714.60.51200.720-254.50.213.40.6180.825-304.20.2312.60.69170.930-3340.25120.75161.033-373.90.2711.60.81151.137-453.70.3110.914.51.245-503.50.3310.50.99141.350-553.40.3510.11.0613.51.455-603.30.389.81.13131.560-653.20.49.51.1912.81.665-703.10.429.31.2612.51.770-8030.4591.3512.31.8>802.90.478.71.42121.9 For deep sedation and analgesia with butorphanolDog
weight
Dexmedetomidine
300 mcg/m
intramuscularly
(kg) (mcg/kg)(mL)2-3 240.123-4 230.164-5 22.20.25-10 16.70.25
For deep sedation and analgesia with butorphanolDog
weight
Dexmedetomidine
300 mcg/m
intramuscularly
(kg) (mcg/kg)(mL)10-13 130.313-15 12.50.3515-20 11.40.420-25 11.10.525-30 100.5530-33 9.50.633-37 9.30.6537-45 8.50.745-50 8.40.850-55 8.10.8555-60 7.80.960-65 7.60.9565-70 7.4170-80 7.31.1>80 71.2
CATS:
The dosage for cats is 40 micrograms dexmedetomidine hydrochloride/kg bw, equal to
a dose volume of 0.08 mL of the veterinary medicinal product/kg bw when used for
non-invasive, mildly to moderately painful procedures requiring restraint, sedation and
analgesia.
When dexmedetomidine is used for premedication in cats, the same dose is used.
Premedication with dexmedetomidine will significantly reduce the dosage of the
induction agent required and will reduce volatile anaesthetic requirements for
maintenance anaesthesia. In a clinical study, the requirement for propofol was reduced
by 50%. All anaesthetic agents used for induction or maintenance of anaesthesia
should be administered to effect.
Anaesthesia can be induced 10 minutes after premedication by intramuscular
administration of a target dose of 5 mg ketamine/ kg bw or by intravenous
administration of propofol to effect. Dosing for cats is presented in the following table.
Cat
weight
Dexmedetomidine 40 mcg/kg intramuscularly
(kg) (mcg/kg)(mL)1-2 400.12-3 400.23-4 400.34-6 400.46-7 400.57-8 400.68-10 400.7
The expected sedative and analgesic effects are reached within 15 minutes after
administration and are maintained up to 60 minutes after administration.
Sedation may be reversed with atipamezole. Atipamezole should not be administered
prior to 30 minutes following ketamine administration.
Do not use in animals with severe systemic disease or in animals that are moribund.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Very common
(> 1 animal / 10
animals
treated):
Bradycardia
Cyanotic mucous membranes
Pale mucous membranes
Common
(1 to 10 animals
/ 100 animals
treated):
Arrhythmia
Rare
(1 to 10 animals
/ 10 000 animals
treated):
Pulmonary oedemaUndetermined
frequency
(cannot be
estimated from
the available
data):
Excitation
Heart block
High blood pressure
Low blood pressure
Premature ventricular contractions
Supraventricular and nodal arrhythmia
Hypersalivation
Retching
Vomiting
Corneal opacity
Muscle tremor
Sedation prolonged
Bradypnoea
1,5
Decreased pulse oxygenation
Decreased respiratory rate
Irregular breathing
Tachypnoea
1,5
Erythema
Decreased body temperature
Urination
1
When dexmedetomidine and butorphanol are used concomitantly.
Due to peripheral vasoconstriction and venous desaturation in the presence of
normal arterial oxygenation.
Blood pressure will increase initially and then return to normal or below normal.
May occur 5–10 minutes after injection. Some dogs may also vomit at the time of
recovery.
When dexmedetomidine is used as a premedicant.
When dexmedetomidine and butorphanol are used concomitantly in dogs, brady- and
tachyarrhythmias have been reported. These may include profound sinus
bradycardia, 1st and 2nd degree AV block, sinus arrest or pause, as well as atrial,
supraventricular and ventricular premature complexes.
When dexmedetomidine is used as a premedicant brady- and tachyarrhythmias have
been reported and include profound sinus bradycardia, 1st and 2nd degree AV block
and sinus arrest. Supraventricular and ventricular premature complexes, sinus pause
and 3rd degree AV block may be observed in rare cases.
Cats:
Very common
(> 1 animal / 10
animals
treated):
Arrhythmia
Bradycardia
Heart block
Vomiting
Pale mucous membranes
Cyanotic mucous membranes
Common
(1 to 10 animals
/ 100 animals
treated):
Supraventricular and nodal arrhythmia
Retching
Decreased pulse oxygenation
Hypothermia
Uncommon
(1 to 10 animals
/ 1 000 animals
treated):
Apnoea
Rare
(1 to 10 animals
/ 10 000 animals
treated):
Pulmonary oedemaUndetermined
frequency
(cannot be
estimated from
the available
data):
Extrasystole
High blood pressure
Low blood pressure
Corneal opacity
Muscle tremor
Bradypnoea
Decreased respiratory rate
Hypoventilation
Irregular breathing
Agitation
1
When dexmedetomidine is used as a premedicant.
When dexmedetomidine and ketamine are used sequentially.
May occur 5–10 minutes after injection. Some cats may also vomit at the time of
recovery.
Due to peripheral vasoconstriction and venous desaturation in the presence of
normal arterial oxygenation.
Blood pressure will increase initially and then return to normal or below normal.
Intramuscular dosing at 40 micrograms/kg (followed by ketamine or propofol)
frequently resulted in sinus bradycardia and sinus arrhythmia, occasionally resulted
in 1st degree atrioventricular block, and rarely resulted in supraventricular premature
depolarizations, atrial bigeminy, sinus pauses, 2nd degree atrioventricular block, or
escape beats/rhythms.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
younger than 12 weeks has not been studied.
Special precautions for safe use in the target species:
Treated animals should be kept warm and at a constant temperature, both during the
procedure and recovery.
It is recommended that animals are fasted for 12 hours prior to administration of the
veterinary medicinal product. Water may be given.
After treatment, the animal should not be given water or food before it is able to
swallow.
Corneal opacities may occur during sedation. The eyes should be protected by a
suitable lubricant.
To be used with precaution in elderly animals.
Nervous, aggressive or excited animals should be given the possibility to calm down
before initiation of treatment.
Frequent and regular monitoring of respiratory and cardiac function should be
performed. Pulse oximetry may be useful but is not essential for adequate monitoring.
Equipment for manual ventilation should be available in case of respiratory depression
or apnoea when dexmedetomidine and ketamine are used sequentially to induce
anaesthesia in cats. It is also advisable to have oxygen readily available, should
hypoxaemia be detected or suspected.
Sick and debilitated dogs and cats should only be premedicated with dexmedetomidine
before induction and maintenance of general anaesthesia based on a risk-benefit
assessment.
Use of dexmedetomidine as a premedicant in dogs and cats significantly reduces the
amount of induction drug required for induction of anaesthesia. Attention should be
given during the administration of intravenous induction drugs to effect. Volatile
anaesthetic requirements for maintenance anaesthesia are also reduced.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product is a sedative. Care should be taken to avoid oral
exposure and self-injection. In case of accidental oral exposure or self-injection, seek
medical advice immediately and show the package leaflet or the label to the physician
but DO NOT DRIVE as sedation and changes in blood pressure may occur.
This veterinary medicinal product can cause skin and/or eye irritation. Care should be
taken to avoid skin, eye and mucosal contact. The use of impermeable gloves is
advisable.
In case of accidental contact of the veterinary medicinal product with the skin or eyes,
rinse with large amounts of fresh water. Remove contaminated clothes that are in direct
contact with skin. If symptoms occur, seek medical advice
If pregnant women handle the veterinary medicinal product, special caution should be
observed not to self-inject as uterine contractions and decreased foetal blood pressure
may occur after accidental systemic exposure.
People with known hypersensitivity to the active substance and/or parabens should
administer the veterinary medicinal product with caution.
To the physician:
The veterinary medicinal product is an agonist, symptoms after
absorption may involve clinical effects including dose-dependent sedation, respiratory
depression, bradycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular
arrhythmias have also been reported. Respiratory and haemodynamic symptoms
should be treated symptomatically. The specific adrenoceptor antagonist,
atipamezole, which is approved for use in animals, has been used in humans only
experimentally to antagonize dexmedetomidine-induced effects.
Special precautions for the protection of the environment:
Not applicable.
effects of dexmedetomidine and therefore an appropriate dose adjustment should be
made. Anticholinergics should be used with caution with dexmedetomidine.
Administration of atipamezole after dexmedetomidine rapidly reverses the effects and
thus shortens the recovery period. Within 15 minutes dogs and cats are normally
awake and standing.
Cats: After administration of 40 micrograms dexmedetomidine/kg bw intramuscularly
concurrently with 5 mg ketamine/kg bw to cats, the maximum concentration of
dexmedetomidine increased twofold but there was no effect on T max. The mean half-
life of elimination of dexmedetomidine increased to 1.6 h and the total exposure (AUC)
increased by 50%.
A dose of 10 mg ketamine/ kg used concurrently with 40 micrograms
dexmedetomidine/ kg may cause tachycardia.
For information on adverse reactions, see section 3.6. Adverse events.
For information on target animal safety in cases of overdosing, see section 3.10.
Symptoms of overdose.
opening the immediate packaging store the product at 20°C - 25°C.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Dexmedetomidine Hydrochloride
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
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