POM-V Prescription Required

CZV Avian Tuberculin PPD

Active ingredient: Mycobacterium avium subsp. avium

Form

Injection

Species

Cattle

Manufacturer

CZ Vaccines S.A.U.

VMD MA No.

30824/4000

What it's used for

Intradermal comparative test When used together with CZV Bovine Tuberculin PPD, in vivo diagnosis of cattle from 6 weeks of age that have generated an immu...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Mycobacterium avium subsp. a...

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

CZV Avian Tuberculin PPD — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Intradermal comparative test
When used together with CZV Bovine Tuberculin PPD, in vivo diagnosis of cattle
from 6 weeks of age that have generated an immune response against M. bovis,
AN: 01387/2024 & 01832/2024
differentiating animals reacting to M. bovis from those that have become sensitised to
bovine tuberculin as a result of exposure to other mycobacteria or related genera
(single intradermal comparative tuberculin test).

Shake well before use
Administration
Injection site shall be clipped and cleansed. A fold of skin within clipped area shall be
taken between the forefinger and thumb and measured with callipers and recorded.
The dose of CZV Avian tuberculin PPD shall then be injected by the intradermal route
into the deeper layers of the skin, in a defined area between the first and second third
of the neck. A correct injection shall be confirmed by palpating a small pea-like
swelling at each site of injection.
AN: 01387/2024 & 01832/2024
The distance between the two injections (CZV Avian Tuberculin PPD and CZV
Bovine Tuberculin PPD) in the comparative intradermal test should be approximately
12 – 15 cm. In young animals in which there is no room to separate the sites
sufficiently on one side of the neck, one injection must be made on each side of the
neck at identical sites in the centre of the middle third of the neck.
The skin-fold thickness of each injection site shall be remeasured 72 ± 4 hours after
injection and recorded.
Interpretation of the results:
Avian single intradermal test
The interpretation of reactions shall be based on clinical observations and the
recorded increase in skin-fold thickness at the site of injection 72 ± 4 hours after
injection of tuberculin.
a) Negative reaction: if only limited swelling is observed, with an increase of not more
than 2 mm in the thickness of the fold of skin without clinical signs such as diffuse or
extensive oedema, exudation, necrosis, pain or inflammation of the lymphatic ducts
in that region or of the lymph nodes.
b) Inconclusive reaction: if no clinical signs such as mentioned in a) are observed and
if the increase in skin-fold thickness is more than 2 mm and less than 4 mm.
c) Positive reaction: if clinical signs such as mentioned in a) are observed or there is
an increase of 4 mm or more in the thickness of the fold of skin at the injection site.
Intradermal comparative test when CZV Avian Tuberculin PPD and CZV Bovine
Tuberculin PPD are used together:
a) Positive: a positive bovine PPD reaction which is more than 4 mm greater than the
avian reaction or the presence of clinical signs diffuse or extensive oedema,
exudation, necrosis, pain or inflammation of the lymphatic ducts in that region or of
the lymph nodes.
b) Inconclusive: a positive or inconclusive bovine PPD reaction which is from 1 to 4
mm greater than the avian reaction, and absence of clinical signs.
c) Negative: a negative bovine PPD reaction, or a positive or inconclusive bovine
PPD reaction but which is equal to or less than a positive or inconclusive avian PPD
reaction and the absence of clinical signs in both cases.
No other products except CZV Bovine Tuberculin PPD should be administered
before, at the same time or after the intradermal test near to the injection site.
Animals inconclusive to intradermal comparative test that are not removed by the
competent authority shall be subjected to another test after a minimum of 42 days.
Animals which are not negative to this second test shall be deemed positive to the
test under EU legislation.
AN: 01387/2024 & 01832/2024
Different criteria for interpretation of results may be applied in accordance with
national requirements for bovine TB eradication schemes

None.

Cattle:
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Hyperthermia
1
Transitory increase of the temperature up to a maximum of 41.4 ºC and, within
3 days after injection.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Vaccinate healthy animals only.
Although field experience suggests that there may be no adverse effect when the
product is used in cattle sensitised to M. avium subsp. avium, safety in such animals
has not been specifically tested and established, therefore careful monitoring should
be done.
It is not recommended to repeat the test until at least 42 days have passed since the
previous test in order to avoid false negatives due to a loss of skin responsiveness
during a period of post-test desensitization.
When used in chronically infected animals with severe pathology, the tuberculin test
may be unresponsive.
Newly infected animals may not react to the tuberculin test until the cell mediated
immune response has developed (for most animals this is between 3 – 6 weeks post-
infection).
Post-partum immunosuppresion may give rise to false negative results in cattle that
have recently calved. A lack of sensitivity to the test can occur in cattle that were
recently or concurrently treated with immunosuppressive agents.

Special precautions for safe use in the target species:
The results obtained with this test should be interpreted by taking into account other
resultsobtained in the herd together with and the clinical and epidemiological factors
which have led to the use of this test.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Accidental self-injection may cause an area of intense irritation, especially in
tuberculin-sensitised individuals. It is recommended that, in such an event, seek
medical advice immediately and show the package leaflet or label to the physician. If
pain persists for more than 12 hours after medical examination, seek medical advice
again
Special precautions for the protection of the environment:
Not applicable.
AN: 01387/2024 & 01832/2024

No information is available on the safety and efficacy of this immunological veterinary
medicinal product when used with any other veterinary medicinal product except CZV
Bovine Tuberculin PPD. A decision to use this immunological veterinary medicinal
product before or after any other veterinary medicinal product therefore needs to be
made on a case by case basis.
Care should be taken in the interpretation of tests carried out in cattle which have
been previously vaccinated against bovine tuberculosis or Johne’s disease
(paratuberculosis) because such vaccinations may cause false positive or false
negative results in the tuberculin skin tests N.B. Vaccination of cattle against bovine
tuberculosis is currently forbidden in the EU. Vaccination of cattle against
paratuberculosis may be forbidden in some EU Member States.

Store and transport refrigerated (2 °C – 8 °C).
Do not freeze.
Protect from light.
May be stored and transported up to a maximum of +37 ºC for a period not longer
than 14 days.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.