Cytopoint 40 mg/ml Solution for Injection

Lokivetmab may induce transient or persistent anti-drug antibodies. The induction of
such antibodies is uncommon and may have no effect (transient anti-drug antibodies)
or may result in a noticeable decrease in efficacy (persistent anti-drug antibodies) in
animals that responded to treatment previously.

Revised: December 2023
AN: 03118/2022

Special precautions for use in animals
Avoidance or elimination of the allergen is an important consideration in the
successful treatment of allergic dermatitis. When treating pruritus associated with
allergic dermatitis with lokivetmab, investigate and treat any underlying causes (e.g.
flea allergic dermatitis, contact dermatitis, food hypersensitivity); this product is not
intended to be used as a long-term maintenance therapy if the offending allergen(s)
can be successfully avoided or eliminated. Furthermore, in cases of allergic
dermatitis and atopic dermatitis, it is recommended to investigate and treat
complicating factors, such as bacterial, fungal or parasitic infections/infestations (e.g.
flea and mange).
It is recommended to monitor dogs for bacterial infections associated with atopic
dermatitis, especially during the first weeks of treatment.
If no or limited response is observed within one month after initial dosing, an
improvement in response may be observed after administration of a second dose
one month later. However, if the animal does not show a better response after the
second dose, the veterinary surgeon should consider alternative treatments.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Hypersensitivity reactions, including anaphylaxis, could potentially occur in the case
of accidental self-injection.
Accidental self-injection may result in an immune response to lokivetmab. It is not
expected for this to cause any adverse effects, however, repeated self-administration
may increase the risk of hypersensitivity reactions.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.