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POM-V Prescription Required Companion Animal

Clomicalm 5 mg Tablets for Dogs

Active ingredient: Clomipramine Hydrochloride

Form

Tablet

Species

Dogs

Manufacturer

Virbac

VMD MA No.

05653/5027

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Clomipramine Hydrochloride

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Clomicalm 5 mg Tablets for Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

The veterinary medicinal product should be administered orally at a dose of 1-2
mg/kg clomipramine twice daily to give a total daily dose of 2-4 mg/kg according to
the following table:
Dosage per administrationBody weightClomicalm 5 mgClomicalm 20 mgClomicalm 80 mg1.25 - 2.5 kg½ tablet>2.5 - 5 kg1 tablet>5 - 10 kg½ tablet>10 - 20 kg1 tablet>20 - 40 kg½ tablet>40 - 80 kg1 tablet
To ensure a correct dosage, body weight should be determined as accurately as
possible.
The use of suitably calibrated measuring equipment is recommended.
The veterinary medicinal product may be given orally with or without food.
In clinical trials, a treatment time of 2-3 months with the veterinary medicinal product
in combination with behavioural modification techniques was sufficient to control the
symptoms of separation-related disorders. Some cases may require longer
treatment. In cases showing no improvement after 2 months, treatment with the
veterinary medicinal product should be ceased.
Do not use in cases of hypersensitivity to the active substance, to any of the
excipients or to related tricyclic antidepressants.
Do not use in male breeding dogs.
Dogs:
Very rare
(< 1 animal / 10,000 animals
treated, including isolated
reports):
Vomiting
1,2
,

Diarrhoea
Appetite disorder
, Lethargy
Elevated liver enzymes
Convulsion, Mydriasis
Agression
Undetermined frequency
(cannot be estimated from the
available data):
Hepato-biliary disorder
1
May be reduced by co-administration of the veterinary medicinal product with a
small quantity of food.
Reversible when the veterinary medicinal product is discontinued.
Especially with pre-existing conditions, and concurrent administrations of medicinal
products metabolised via the hepatic system.
Can also be observed following overdose.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
The efficacy and safety of the veterinary medicinal product has not been established
in dogs weighing less than 1.25 kg or under six months of age.

Special precautions for safe use in the target species:
It is recommended that the veterinary medicinal product be administered to dogs with
cardiovascular dysfunction or epilepsy with caution and only after an assessment of
the benefit-risk ratio. Because of its potential anticholinergic properties, the veterinary
medicinal product should also be used with care in dogs with narrow-angle
glaucoma, reduced gastrointestinal motility or urinary retention. The veterinary
medicinal product should be used under veterinary supervision.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In children, accidental ingestion should be regarded as serious. There is no specific
antidote. In case of accidental ingestion, seek medical advice immediately and show
the package leaflet or the label to the physician. Overdose in human beings causes
anticholinergic effects although central nervous and cardiovascular systems may also
be affected. People with known hypersensitivity to clomipramine should administer
the veterinary medicinal product with caution.
Special precautions for the protection of the environment:
Not applicable.
Recommendations on the interaction between the veterinary medicinal product and
other medicaments are derived from studies in species other than dogs. the
veterinary medicinal product may potentiate the effects of the anti-arrhythmic
medicinal products quinidine, anticholinergic agents (e.g. atropine), other central
nervous system (CNS) medicinal products (e.g. barbiturates, benzodiazepines,
general anaesthetics, neuroleptics), sympathomimetics (e.g. adrenaline) and
coumarin derivatives. The administration of the veterinary medicinal product is not
recommended in combination with, or within 2 weeks of therapy with monoamine
oxidase inhibitors. Simultaneous administration with cimetidine may lead to increased
plasma levels of clomipramine. Plasma levels of certain anti-epileptic medicinal
products, such as phenytoin and carbamazepine, may be increased by co-
administration with the veterinary medicinal product.
Store in the original container.
Not applicable.
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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