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NFA-VPS Over the Counter Companion Animal

Cestem Flavoured Tablets for Large Dogs

Active ingredients: Febantel, Praziquantel, Pyrantel

Form

Tablet

Species

Dogs

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/5053

What it's used for

Hookworms: Uncinaria stenocephala (adults). Whipworms: (adults). Cestodes: Tapeworms: spp., Taenia (adult and immature forms).

Full indications, dosage and side effects ↓
View official SPC (PDF)

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  1. 1

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Clinical information

Cestem Flavoured Tablets for Large Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Hookworms: Uncinaria stenocephala (adults).
Whipworms: (adults).
Cestodes:
Tapeworms: spp., Taenia (adult and immature
forms).
mg febantel/kg

bodyweight

,
mg

pyrantel

(as

embonate)/kg bodyweight

and
mg praziquantel/kg bodyweight. This is equivalent to 1 tablet per 35 kg
bodyweight, in one administration.
Dosages are as follows:
Body weight (kg)Tablet quantity17.5½>17.5 – 351>35 – 52.51 ½>52.5 – 702
The smaller tablet size should be used to achieve accurate dosing in dogs
weighing less than 17.5 kg.
The tablets can be given to the dog with or without food. No starvation is needed
before or after treatment.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
The dosing program should be established by the veterinary surgeon.
As a general rule, puppies should be treated at 2 weeks of age and every 2 weeks
until 12 weeks of age. Thereafter they should be treated at 3 month intervals. It is
advisable to treat the bitch at the same time as the puppies.
For the control of , nursing bitches should be dosed 2 weeks after
giving birth and every two weeks until weaning.
For routine worm control adult dogs should be treated every 3 months.
In case of confirmed single infestation by cestode or by nematode, a monovalent
product containing a cestocide or a nematocide alone should be preferred.
For routine treatment a single dose is recommended.
In the event of heavy roundworm infestation a repeat dose should be given after 14
days.
If an infestation caused by Echinococcus (E.granulosus) is detected in dogs, a
repetition of the treatment is recommended for safety purpose.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Dogs:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Vomiting, Diarrhoea
Lethargy
1
associated with vomiting and/or diarrhoea
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class.
Fleas serve as intermediate hosts for one common type of tapeworm –
caninum. Tapeworm infection may reoccur unless control of intermediate hosts such
as fleas, mice etc is undertaken.

Special precautions for safe use in the target species:
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Wash hands after administration to the animal.
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician.
People with known hypersensitivity to any of the ingredients should avoid contact with
the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
Since it contains praziquantel, the product is effective against spp.
which do not occur in all EU member states but are becoming more common in some.
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable
disease to the World Organisation for Animal Health (WOAH), specific guidelines on
the treatment and follow-up, and on the safeguard of persons, need to be obtained
from the relevant competent authority.
Do not use simultaneously with piperazine, as the anthelmintic effects of pyrantel
and piperazine may be antagonized.
Plasma concentrations of praziquantel may be decreased by concomitant
administration with drugs that increase the activity of cytochrome P-450 enzymes
(e.g. dexamethasone, phenobarbital).
Concurrent use with other cholinergic compounds can lead to toxicity.
This veterinary medicinal product does not require any special storage conditions.
Return any halved tablet to the opened blister pack .
Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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