Cartrophen Vet 100 mg/ml Solution for Injection for Dogs

Emesis, diarrhoea, lethargy and anorexia have been reported following the use of
pentosan polysulfate. These signs may be the result of a hypersensitivity reaction
and may require appropriate symptomatic treatment including antihistamine
administration.

Administration of the product at recommended dose rates results in increases of
activated partial thromboplastin time (aPTT) and thrombin time (TT) which may
persist for up to 24 hours after administration in healthy dogs. This very rarely results
in clinical effects, but because of the fibrinolytic action of pentosan polysulfate
sodium, the possibility of internal bleeding from a tumour or vascular abnormality
should be considered if signs develop. It is recommended that the animal should be
monitored for signs of blood loss and treated appropriately

Bleeding disorders such as nasal bleeding, haemorrhagic diarrhoea and
haematomas have been reported.

Local reactions such as a transient swelling have been observed post injection.